MMWR Morb Mortal Wkly Rep. 2015 Jan 30;64(3):54-7.
Fetal alcohol syndrome (FAS) is a serious birth defect and developmental disorder caused by in utero exposure to alcohol. Assessment of the public health burden of FAS through surveillance has proven difficult; there is wide variation in reported prevalence depending on the study population and surveillance method. Generally, records-based birth prevalence studies report estimates of 0.2-1.5 per 1,000 live births, whereas studies that use in-person, expert assessment of school-aged children in a community report estimates of 6-9 per 1,000 population. The Fetal Alcohol Syndrome Surveillance Network II addressed some of the challenges in records-based ascertainment by assessing a period prevalence of FAS among children aged 7‒9 years in Arizona, Colorado, and New York. The prevalence across sites ranged from 0.3 to 0.8 per 1,000 children. Prevalence of FAS was highest among American Indian/Alaska Native children and lowest among Hispanic children. These estimates continue to be much lower than those obtained from studies using in-person, expert assessment. Factors that might contribute to this discrepancy include 1) inadequate recognition of the physical and behavioral characteristics of FAS by clinical care providers; 2) insufficient documentation of those characteristics in the medical record; and 3) failure to consider prenatal alcohol exposure with diagnoses of behavioral and learning problems. Addressing these factors through training of medical and allied health providers can lead to practice changes, ultimately increasing recognition and documentation of the characteristics of FAS.
胎儿酒精谱系障碍(FAS)是一种严重的出生缺陷和发育障碍,由子宫内暴露于酒精引起。通过监测评估 FAS 的公共卫生负担证明是困难的;由于研究人群和监测方法的不同,报告的患病率差异很大。一般来说,基于记录的出生患病率研究报告的估计值为每 1000 例活产中有 0.2-1.5 例,而使用面对面、对社区学龄儿童进行专家评估的研究报告的估计值为每 1000 人中 6-9 例。胎儿酒精谱系障碍监测网络 II 通过评估亚利桑那州、科罗拉多州和纽约州 7-9 岁儿童的 FAS 现患率,解决了基于记录的确定方法中的一些挑战。各地点的患病率从每 1000 名儿童 0.3 到 0.8 例不等。FAS 的患病率在美洲印第安人/阿拉斯加原住民儿童中最高,在西班牙裔儿童中最低。这些估计值仍然远低于使用面对面、专家评估的研究获得的估计值。导致这种差异的因素可能包括:1)临床护理提供者对 FAS 的身体和行为特征认识不足;2)在医疗记录中对这些特征的记录不足;3)在诊断行为和学习问题时未能考虑到产前酒精暴露。通过对医疗和相关健康提供者进行培训来解决这些因素,可以导致实践的改变,最终增加对 FAS 特征的认识和记录。