胎儿酒精谱系障碍：与产前酒精暴露相关的神经行为缺陷综述。
Fetal Alcohol Spectrum Disorders: A Review of the Neurobehavioral Deficits Associated With Prenatal Alcohol Exposure.
机构信息
Center for Behavioral Teratology and Department of Psychology, San Diego State University, San Diego, California.
出版信息
Alcohol Clin Exp Res. 2019 Jun;43(6):1046-1062. doi: 10.1111/acer.14040. Epub 2019 May 2.
Abstract
In utero alcohol exposure can disrupt the development of the fetal brain and result in a wide range of neurobehavioral outcomes collectively known as fetal alcohol spectrum disorders (FASD). This paper provides a comprehensive review of the cognitive and behavioral outcomes of prenatal alcohol exposure, including domains of general intelligence, executive functioning, language development, learning and memory, adaptive functioning, academic performance, and concurrent psychopathology. In addition, the current status of the neurobehavioral profile of FASD and its potential as a diagnostic tool will be discussed.
摘要
胎儿期酒精暴露可干扰胎儿大脑发育，导致一系列被统称为胎儿酒精谱系障碍（FASD）的神经行为后果。本文全面综述了产前酒精暴露的认知和行为后果，包括一般智力、执行功能、语言发展、学习和记忆、适应功能、学业成绩以及并发精神病理学等领域。此外，还将讨论 FASD 的神经行为特征及其作为诊断工具的潜在用途的现状。
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本文引用的文献
1
Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities.
JAMA. 2018 Feb 6;319(5):474-482. doi: 10.1001/jama.2017.21896.
2
Accentuate the Negative: Grammatical Errors During Narrative Production as a Clinical Marker of Central Nervous System Abnormality in School-Aged Children With Fetal Alcohol Spectrum Disorders.
J Speech Lang Hear Res. 2017 Dec 20;60(12):3523-3537. doi: 10.1044/2017_JSLHR-L-17-0128.
3
Altered functional connectivity during spatial working memory in children with heavy prenatal alcohol exposure.
Alcohol. 2017 Nov;64:11-21. doi: 10.1016/j.alcohol.2017.05.002. Epub 2017 Aug 12.
4
Intelligence and Fetal Alcohol Spectrum Disorders: A Review.
J Popul Ther Clin Pharmacol. 2017 Jan 8;24(3):e1-e18. doi: 10.22374/1710-6222.24.3.1.
5
Facial Curvature Detects and Explicates Ethnic Differences in Effects of Prenatal Alcohol Exposure.
Alcohol Clin Exp Res. 2017 Aug;41(8):1471-1483. doi: 10.1111/acer.13429. Epub 2017 Jul 10.
6
Comorbid Mental Disorders in Fetal Alcohol Spectrum Disorders: A Systematic Review.
J Dev Behav Pediatr. 2017 May;38(4):283-291. doi: 10.1097/DBP.0000000000000440.
7
Academic Difficulties in Children with Prenatal Alcohol Exposure: Presence, Profile, and Neural Correlates.
Alcohol Clin Exp Res. 2017 May;41(5):1024-1034. doi: 10.1111/acer.13366. Epub 2017 Mar 24.
8
Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol.
Alcohol Clin Exp Res. 2017 Feb;41(2):334-344. doi: 10.1111/acer.13307. Epub 2017 Jan 11.
9
An ERP Study of Response Inhibition in the Auditory Domain in Children with Fetal Alcohol Spectrum Disorders.
Alcohol Clin Exp Res. 2017 Jan;41(1):96-106. doi: 10.1111/acer.13263. Epub 2016 Dec 7.
10
Special Education of Children with Fetal Alcohol Spectrum Disorder.
Exceptionality. 2016 Jul 2;24(3):165-175. doi: 10.1080/09362835.2015.1064415. Epub 2016 Mar 23.
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