Waite Alison J, Coombs Robert C, McKenzie Angela, Daman-Willems Charlotte, Cohen Marta C, Campbell Michael J, Carpenter Robert G
Academic Unit of Child Health, University of Sheffield, Sheffield Children's Hospital, Sheffield, UK.
Sheffield Teaching Hospitals, Sheffield, UK.
Arch Dis Child. 2015 Jul;100(7):637-42. doi: 10.1136/archdischild-2014-307232. Epub 2015 Jan 29.
To report mortality in babies enrolled on a community-based programme, Care of Next Infant Plus (CONI PLUS), which primarily supports parents anxious because of previous sudden unexpected death in infancy (SUDI) in their extended family or following an apparent life threatening event (ALTE) in their baby.
Prospective observational study from 1996 to 2010 in the UK.
Of 6487 babies enrolled, 37 died (5.7 per 1000). There were 2789 (43.0%) SUDI related babies of whom, six died suddenly and unexpectedly (2.15 per 1000). Four babies were sharing a sofa at night or a bed with parent(s) who smoked or had consumed alcohol. Of the 1882 (29.0%) babies enrolled following an ALTE, five died suddenly and unexpectedly (2.66 per 1000): four unexplained and one due to infection. None occurred while sharing a sleep surface, and at least three died during the day. The remaining 1816 (28%) babies were enrolled for other reasons. Seven died suddenly and unexpectedly (3.85 per 1000), two were unexplained and none associated with bed sharing.
The number of SUDI deaths in babies enrolled on CONI PLUS is higher than expected from UK averages. Deaths in babies enrolled because of family history of SUDI were mostly associated with inappropriate sharing of a sleep surface at night and mostly outside the peak age range for sudden infant death. The opposite is true for those enrolled following an ALTE. The number of deaths is small but findings suggest a different mechanism for death in these two groups.
报告参加一项社区项目“关爱下一婴儿升级版（CONI PLUS）”的婴儿的死亡率。该项目主要为因大家庭中先前发生婴儿不明原因猝死（SUDI）或其婴儿发生明显危及生命事件（ALTE）而焦虑的父母提供支持。
1996年至2010年在英国进行的前瞻性观察性研究。
在登记的6487名婴儿中，有37名死亡（每1000名中有5.7名）。有2789名（43.0%）与SUDI相关的婴儿，其中6名突然意外死亡（每1000名中有2.15名）。4名婴儿晚上与吸烟或饮酒的父母共用沙发或同床。在因ALTE而登记的1882名（29.0%）婴儿中，有5名突然意外死亡（每1000名中有2.66名）：4例死因不明，1例死于感染。没有死亡发生在共用睡眠表面时，且至少3例在白天死亡。其余1816名（28%）婴儿因其他原因登记。7名突然意外死亡（每1000名中有3.85名），2例死因不明，且均与同床无关。
参加CONI PLUS项目的婴儿中SUDI死亡人数高于英国平均预期。因SUDI家族史而登记的婴儿死亡大多与夜间睡眠表面共用不当有关，且大多不在婴儿猝死的高峰年龄范围内。因ALTE而登记的婴儿情况则相反。死亡人数虽少，但研究结果表明这两组婴儿的死亡机制不同。
