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Front Immunol. 2021 Nov 19;12:738041. doi: 10.3389/fimmu.2021.738041. eCollection 2021.
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Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats.含有多个端粒 TTAGGG 基序的合成寡脱氧核苷酸可抑制缺氧缺糖巨噬细胞中的炎性小体活性，并减轻易卒中型自发性高血压大鼠的缺血性脑损伤。
PLoS One. 2015 Oct 16;10(10):e0140772. doi: 10.1371/journal.pone.0140772. eCollection 2015.

本文引用的文献

1
Inhibitory/suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice.抑制性/抑制性寡脱氧核苷酸纳米胶囊作为预防小鼠特应性皮炎的简易口服给药装置。
Mol Ther. 2015 Feb;23(2):297-309. doi: 10.1038/mt.2014.239. Epub 2014 Dec 15.
2
Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer.CpG寡核苷酸作为针对传染病和癌症的疫苗佐剂的临床评估。
Vaccine. 2014 Nov 12;32(48):6377-89. doi: 10.1016/j.vaccine.2014.06.065. Epub 2014 Jun 24.
3
The microbiome and regulation of mucosal immunity.微生物组与黏膜免疫的调控。
Immunology. 2014 May;142(1):24-31. doi: 10.1111/imm.12231.
4
Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression.I 类/II 类混合抑制性寡脱氧核苷酸发挥 Th1 和 Th2 双重免疫抑制作用。
FEBS Open Bio. 2012 Nov 12;3:41-5. doi: 10.1016/j.fob.2012.11.002. Print 2013.
5
Toll-like receptor signaling and regulation of intestinal immunity.Toll 样受体信号转导与肠道免疫调控。
Virulence. 2013 Apr 1;4(3):207-12. doi: 10.4161/viru.23354. Epub 2013 Jan 18.
6
Intratumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells.瘤内注射 CpG 寡核苷酸可诱导髓源性抑制细胞的分化并降低其免疫抑制活性。
J Immunol. 2012 Feb 15;188(4):1592-9. doi: 10.4049/jimmunol.1101304. Epub 2012 Jan 9.
7
Therapeutic applications and mechanisms underlying the activity of immunosuppressive oligonucleotides.免疫抑制寡核苷酸活性的治疗应用及作用机制。
Ann N Y Acad Sci. 2009 Sep;1175:80-8. doi: 10.1111/j.1749-6632.2009.04970.x.
8
Therapeutic potential of Toll-like receptor 9 activation.Toll样受体9激活的治疗潜力。
Nat Rev Drug Discov. 2006 Jun;5(6):471-84. doi: 10.1038/nrd2059.
9
Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock.抑制性寡脱氧核苷酸可保护小鼠免受致死性内毒素休克的影响。
J Immunol. 2005 Apr 15;174(8):4579-83. doi: 10.4049/jimmunol.174.8.4579.
10
Immunotherapeutic uses of CpG oligodeoxynucleotides.CpG寡脱氧核苷酸的免疫治疗用途。
Nat Rev Immunol. 2004 Apr;4(4):249-58. doi: 10.1038/nri1329.

Therapeutic implications of orally delivered immunomodulatory oligonucleotides.

作者信息

Klinman Dennis M

机构信息

Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.

出版信息

Mol Ther. 2015 Feb;23(2):222-3. doi: 10.1038/mt.2014.251.

DOI:10.1038/mt.2014.251
PMID:25633172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4445629/
Abstract
摘要