Seo Yukako, Nonaka Manabu, Tagaya Etsuko, Tamaoki Jun, Yoshihara Toshio
Department of Otolaryngology, Tokyo Women's Medical University, Tokyo, Japan.
ORL J Otorhinolaryngol Relat Spec. 2015;77(1):1-9. doi: 10.1159/000370122. Epub 2015 Jan 29.
Eosinophilic otitis media (EOM) is an intractable otitis media characterized by an accumulation of eosinophils in the middle ear and a strong association with asthma. We investigated the relationship between EOM and asthma severity, asthma risk factors, lung function, and airway structural changes assessed by high-resolution computed tomographic (HRCT) scanning.
Forty-one asthma patients with chronic rhinosinusitis (18 men and 23 women; mean age 56 years; age range 25-82 years) were included in this study. EOM was diagnosed according to the published diagnostic criteria. Asthma severity and risk factors for asthma, such as smoking history (Brinkman index, BI), were examined. Airway wall thickness and emphysema were assessed with HRCT scanning by a blinded respiratory specialist using a validated method. Lung function was measured using standard procedures.
EOM was diagnosed in 34% of the patients. Asthma severity, BI and airway wall thickness were each statistically greater in patients with EOM than in patients without EOM.
There was a close relationship between EOM and asthma severity in asthma patients with chronic rhinosinusitis. Cessation of smoking might help prevent EOM by reducing airway wall thickness.
嗜酸性粒细胞性中耳炎（EOM）是一种难治性中耳炎，其特征是中耳内嗜酸性粒细胞积聚且与哮喘密切相关。我们研究了EOM与哮喘严重程度、哮喘危险因素、肺功能以及通过高分辨率计算机断层扫描（HRCT）评估的气道结构变化之间的关系。
本研究纳入了41例患有慢性鼻窦炎的哮喘患者（18例男性和23例女性；平均年龄56岁；年龄范围25 - 82岁）。EOM根据已发表的诊断标准进行诊断。检查哮喘严重程度以及哮喘的危险因素，如吸烟史（布林克曼指数，BI）。由一位盲法呼吸专科医生使用经过验证的方法通过HRCT扫描评估气道壁厚度和肺气肿情况。使用标准程序测量肺功能。
34%的患者被诊断为EOM。EOM患者的哮喘严重程度、BI和气道壁厚度在统计学上均高于无EOM的患者。
在患有慢性鼻窦炎的哮喘患者中，EOM与哮喘严重程度之间存在密切关系。戒烟可能通过减少气道壁厚度有助于预防EOM。
