儿童哮喘与中耳炎之间的双向关联。
Bidirectional association between asthma and otitis media in children.
作者信息
Kim So Young, Kim Hye-Rim, Min Chanyang, Choi Hyo Geun
机构信息
Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
出版信息
Allergy Asthma Clin Immunol. 2021 Jan 9;17(1):7. doi: 10.1186/s13223-020-00500-7.
BACKGROUND
This study explored the reciprocal association between otitis media and asthma in children.
METHODS
The 2002-2013 Korean Health Insurance Review and Assessment Service-National Sample Cohort participants < 15 years old were used. In study I, 14,665 asthma patients from 2002 through 2005 were selected. The asthma patients were matched 1:1 with the control I group, and the occurrence of otitis media was followed until 2013. In study II, 27,043 otitis media patients from 2002 through 2005 were selected. The otitis media patients were matched 1:1 with the control II group, and the occurrence of asthma was followed until 2013. Stratified Cox proportional hazard models were used to analyze the hazard ratio (HRs) of asthma for otitis media (study I) and otitis media for asthma (study II).
RESULTS
The HR for otitis media was 1.46 in asthma patients (95% confidence interval [CI] = 1.40-1.52, P < 0.001). The HR for asthma was 1.43 in otitis media patients (95% confidence interval [CI] = 1.36-1.50, P < 0.001).
CONCLUSION
Asthma and otitis media have a bidirectional association in children.
背景
本研究探讨了儿童中耳炎与哮喘之间的相互关联。
方法
使用2002 - 2013年韩国健康保险审查与评估服务机构的全国样本队列中15岁以下的参与者。在研究I中，选取了2002年至2005年的14665名哮喘患者。哮喘患者与对照组I按1:1匹配，并随访至2013年中耳炎的发生情况。在研究II中，选取了2002年至2005年的27043名中耳炎患者。中耳炎患者与对照组II按1:1匹配，并随访至2013年哮喘的发生情况。采用分层Cox比例风险模型分析中耳炎患者患哮喘的风险比（HRs）（研究I）以及哮喘患者患中耳炎的风险比（研究II）。
结果
哮喘患者患中耳炎的HR为1.46（95%置信区间[CI]=1.40 - 1.52，P<0.001）。中耳炎患者患哮喘的HR为1.43（95%置信区间[CI]=1.36 - 1.50，P<0.001）。
结论
哮喘与中耳炎在儿童中存在双向关联。
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