Rupp Stefan, Schranz Dietmar
Pediatric Heart Center, University of Giessen and Marburg, Feulgenstrasse 12, 35390, Giessen, Germany,
Pediatr Cardiol. 2015 Apr;36(4):713-8. doi: 10.1007/s00246-015-1120-x. Epub 2015 Jan 30.
Very young mammals have an impressive cardiac regeneration capacity. In contrast, cardiac regeneration is very limited in adult humans. The hearts of young children have a higher regenerative capacity compared with adults, as, for example, seen after surgical correction of an anomalous left coronary artery arising from the pulmonary artery or in children with univentricular hearts, who present enormous morphological changes after volume unloading. In addition, the enormous regenerative potential of growing children's hearts is reflected in the spontaneous courses of children with severely deteriorated cardiac function (e.g., patients with dilated cardiomyopathy). The extent of this regenerative capacity and its time dependency remain to be elucidated in the future and should be exploited to improve the treatment of children with severe heart insufficiency.
非常年幼的哺乳动物具有令人印象深刻的心脏再生能力。相比之下，成年人类的心脏再生能力非常有限。与成年人相比，幼儿的心脏具有更高的再生能力，例如，在对源自肺动脉的异常左冠状动脉进行手术矫正后，或者在单心室心脏的儿童中，这些儿童在容量卸载后会出现巨大的形态变化。此外，心脏功能严重恶化的儿童（如扩张型心肌病患者）的自然病程也反映了成长中儿童心脏巨大的再生潜力。这种再生能力的程度及其时间依赖性仍有待未来阐明，应加以利用以改善重症心力衰竭儿童的治疗。
