Kuriu A, Fujita J, Kanakura Y, Yonezawa T, Yoshida K, Kitamura Y
Division of Cancer Pathology, Osaka University Medical School, Japan.
Leuk Res. 1989;13(1):77-82. doi: 10.1016/0145-2126(89)90034-9.
L-8313 is a murine T-cell leukemia cell line the cells of which constitutively produce interleukin-3 (IL-3). S2-8313 is a unique subline of L-8313 which has lost IL-3 producing activity. Although the growth of S2-8313 cells in the bone marrow is comparable to that of L-8313 cells, the survival time of C3H mice grafted with S2-8313 cells is significantly shorter than that of C3H mice grafted with L-8313 cells. The accelerated death observed in C3H mice bearing S2-8313 cells is attributable to early development of granulocytopenia and thrombocytopenia, which resulted from the loss of the IL-3 producing activity.
L-8313是一种小鼠T细胞白血病细胞系，其细胞可组成性产生白细胞介素-3（IL-3）。S2-8313是L-8313的一个独特亚系，已丧失产生IL-3的活性。尽管S2-8313细胞在骨髓中的生长情况与L-8313细胞相当，但移植了S2-8313细胞的C3H小鼠的存活时间明显短于移植了L-8313细胞的C3H小鼠。在携带S2-8313细胞的C3H小鼠中观察到的加速死亡归因于粒细胞减少症和血小板减少症的早期发展，这是由于产生IL-3活性的丧失所致。
