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微血管性心绞痛的病因发病机制:我们认知中的注意事项。

Etiopathogenesis of microvascular angina: caveats in our knowledge.

作者信息

Mittal S R

机构信息

Department of Cardiology, Mittal Hospital & Research Centre, Pushkar Road, Ajmer, Rajasthan 305001, India.

出版信息

Indian Heart J. 2014 Nov-Dec;66(6):678-81. doi: 10.1016/j.ihj.2014.10.407. Epub 2014 Nov 4.

DOI:10.1016/j.ihj.2014.10.407
PMID:25634404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4310995/
Abstract

Nearly 50% of subjects of coronary artery disease suffer from coronary microvascular dysfunction. Various etiopathogenetic factors have been proposed by different workers but no hypothesis can explain the genesis of microvascular angina in all patients. We have made an attempt to review the literature to find caveats in our knowledge so that future studies can be better designed.

摘要

近50%的冠状动脉疾病患者存在冠状动脉微血管功能障碍。不同的研究人员提出了各种病因学因素,但没有一种假说能解释所有患者微血管性心绞痛的发病机制。我们试图回顾文献以找出我们知识中的不足,以便更好地设计未来的研究。

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Etiopathogenesis of microvascular angina: caveats in our knowledge.微血管性心绞痛的病因发病机制:我们认知中的注意事项。
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2
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本文引用的文献

1
Impaired coronary microvascular reactivity in women with apical ballooning syndrome (Takotsubo/stress cardiomyopathy).女性心尖球囊综合征(Takotsubo/应激性心肌病)患者的冠状动脉微血管反应受损。
Eur Heart J Acute Cardiovasc Care. 2013 Jun;2(2):147-52. doi: 10.1177/2048872613475891.
2
Flow in the left anterior descending coronary artery in patients with migraine headache.偏头痛患者左前降支冠状动脉血流。
Am J Cardiol. 2013 Nov 15;112(10):1540-4. doi: 10.1016/j.amjcard.2013.06.029. Epub 2013 Aug 22.
3
Prevalence of metabolic syndrome, insulin resistance, and microvascular angina pectoris in 500 consecutive patients referred to coronarography.500例连续接受冠状动脉造影患者的代谢综合征、胰岛素抵抗和微血管性心绞痛患病率
Endocr Regul. 2013 Jan;47(1):33-8. doi: 10.4149/endo_2013_01_33.
4
Microvascular coronary artery spasm presents distinctive clinical features with endothelial dysfunction as nonobstructive coronary artery disease.微血管性冠状动脉痉挛表现为非阻塞性冠状动脉疾病的内皮功能障碍的独特临床特征。
J Am Heart Assoc. 2012 Oct;1(5):e002485. doi: 10.1161/JAHA.112.002485. Epub 2012 Oct 25.
5
Obesity: a new risk factor for cardiac syndrome X? Editorial to: "Obesity, inflammation and brachial artery flow-mediated dilatation: therapeutic targets in patients with microvascular angina (cardiac syndrome X)" by P. Ong et al.肥胖:心脏X综合征的一个新的危险因素?对P. Ong等人所著《肥胖、炎症与肱动脉血流介导的扩张:微血管性心绞痛(心脏X综合征)患者的治疗靶点》一文的编者按
Cardiovasc Drugs Ther. 2012 Jun;26(3):191-2. doi: 10.1007/s10557-012-6390-4.
6
Coronary microvascular function and cortical pain processing in patients with silent positive exercise testing and normal coronary arteries.静息运动试验阳性且冠状动脉正常患者的冠状动脉微血管功能与皮质痛觉处理。
Am J Cardiol. 2012 Jun 15;109(12):1705-10. doi: 10.1016/j.amjcard.2012.02.012. Epub 2012 Mar 27.
7
Patients with syndrome X have normal transmural myocardial perfusion and oxygenation: a 3-T cardiovascular magnetic resonance imaging study.综合征 X 患者具有正常的跨壁心肌灌注和氧合:一项 3-T 心血管磁共振成像研究。
Circ Cardiovasc Imaging. 2012 Mar;5(2):194-200. doi: 10.1161/CIRCIMAGING.111.969667. Epub 2012 Feb 8.
8
High prevalence of a pathological response to acetylcholine testing in patients with stable angina pectoris and unobstructed coronary arteries. The ACOVA Study (Abnormal COronary VAsomotion in patients with stable angina and unobstructed coronary arteries).在稳定型心绞痛且冠状动脉无阻塞的患者中,乙酰胆碱检测存在病理性反应的高发率。ACOVA 研究(稳定型心绞痛和冠状动脉无阻塞患者的异常冠状动脉血管舒缩功能)。
J Am Coll Cardiol. 2012 Feb 14;59(7):655-62. doi: 10.1016/j.jacc.2011.11.015.
9
Microvascular dysfunction: What have we learned from WISE?微血管功能障碍:我们从WISE研究中学到了什么?
Expert Rev Cardiovasc Ther. 2011 Dec;9(12):1491-4. doi: 10.1586/erc.11.165.
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Endothelial dysfunction as assessed by flow-mediated dilation in patients with cardiac syndrome X: role of inflammation.心脏 X 综合征患者的血流介导扩张评估的内皮功能障碍:炎症的作用。
Eur Rev Med Pharmacol Sci. 2011 Sep;15(9):1074-7.