Huser Martin, Wagnerova Kristyna, Janku Petr, Malaskova Lenka, Stourac Petr
Department of Obstetrics and Gynecology, Brno University Hospital and Masaryk University Medical School, Brno, Czech Republic.
Gynecol Obstet Invest. 2015;79(2):73-7. doi: 10.1159/000369998. Epub 2015 Jan 28.
BACKGROUND/AIMS: Goodpasture syndrome (GS) is an autoimmune disease affecting mainly the kidneys and lungs. This review article focuses on GS occurring during pregnancy, which can seriously threaten the lives of both mother and fetus. We summarize the current clinical diagnosis and management of GS in pregnancy.
A profound literature search was carried out to review all published articles or case studies reporting on GS in pregnancy. We extracted the following data from each case: patient age, parity, gestational age, therapy of GS during pregnancy, pregnancy outcome, neonatal outcome, mode of delivery, and the patient's kidney status. We describe in detail how a recent case of GS diagnosed in pregnancy was successfully treated.
A review of the available literature revealed 4 cases of GS in pregnancy. The average patient age was 29.3 ± 2.5 years, and most were primiparous, with an average parity of 1.3 ± 1.5. The average gestational age at the time of diagnosis was 12.5 ± 5.9 weeks. The therapies of GS during pregnancy were remarkably varied. Furthermore, the neonatal outcomes were also quite individual among the observed cases.
The occurrence of GS during pregnancy is very rare. This unusual pregnancy complication is associated with significant maternal and fetal morbidity. The management of GS during pregnancy requires intensive care and multidisciplinary cooperation.
背景/目的：肺出血肾炎综合征（GS）是一种主要影响肾脏和肺部的自身免疫性疾病。这篇综述文章聚焦于孕期发生的GS，它会严重威胁母婴生命。我们总结了孕期GS目前的临床诊断和治疗方法。
进行了深入的文献检索，以回顾所有已发表的关于孕期GS的文章或病例研究。我们从每个病例中提取了以下数据：患者年龄、产次、孕周、孕期GS的治疗方法、妊娠结局、新生儿结局、分娩方式以及患者的肾脏状况。我们详细描述了最近一例孕期诊断为GS的病例是如何成功治疗的。
对现有文献的回顾发现了4例孕期GS病例。患者平均年龄为29.3±2.5岁，大多数为初产妇，平均产次为1.3±1.5。诊断时的平均孕周为12.5±5.9周。孕期GS的治疗方法差异很大。此外，观察到的病例中新生儿结局也各不相同。
孕期发生GS非常罕见。这种不寻常的妊娠并发症与母婴的严重发病相关。孕期GS的管理需要重症监护和多学科合作。
