Riahi Taghi, Najafi Laily, Asadi Ghadikolaei Omolbanin, Tajik Jalayeri Mohammad Hadi
Hazrate Rasool Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Caspian J Intern Med. 2022 Spring;13(2):442-446. doi: 10.22088/cjim.13.2.442.
Goodpasture syndrome (GPS) rarely affects parturients which may quickly result in severe pulmonary and renal damage with significant fetomaternal morbidity.
A 35-year-old white multiparous lady, presented with acute progressive respiratory failure at 32 gestational age. She had fever, cough, severe dyspnea and lately hemoptysis and severe hypoxia with bilateral alveolar opacity in chest imaging, with no response to broad spectrum antibiotic. GPS diagnosis was confirmed by high anti- glomerular basement membrane (anti GBM) titer, without the similar history in the past parities. High dose intravenous methylprednisolone ended to dramatic clinical response. She was maintained on glucocorticoids for five weeks before the successful delivery of a live healthy fetus at 39 Weeks.
This study demonstrated a successful pregnancy outcome which was achieved in the present GPS parturient with a careful antepartum care involving maternal-fetal status by serial pulmonary, renal monitoring and special treatment of disease.
肺出血肾炎综合征（GPS）很少影响产妇，可能会迅速导致严重的肺和肾损伤，并伴有明显的母婴发病率。
一名35岁的白人经产妇，在孕32周时出现急性进行性呼吸衰竭。她有发热、咳嗽、严重呼吸困难，近期咯血，胸部影像学显示双侧肺泡混浊、严重缺氧，对广谱抗生素无反应。高抗肾小球基底膜（抗GBM）滴度确诊为GPS，既往妊娠无类似病史。大剂量静脉注射甲基强的松龙产生了显著的临床反应。在孕39周成功分娩出一名健康活胎前，她接受了五周的糖皮质激素治疗。
本研究表明，通过对一名患有GPS的产妇进行精心的产前护理，包括通过连续的肺部、肾脏监测和疾病的特殊治疗来关注母婴状况，实现了成功的妊娠结局。
