酮的二氟同系化反应。
Difluorohomologation of ketones.
机构信息
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences , 119991 Moscow, Leninsky prosp. 47, Russian Federation.
出版信息
Org Lett. 2015 Feb 6;17(3):760-3. doi: 10.1021/acs.orglett.5b00097. Epub 2015 Jan 29.
PMID:25634445
Abstract
A method for the homologation of ketones with the CF2 fragment is described. The reaction involves silylation, room-temperature difluorocyclopropanation of silyl enol ethers, and selective ring opening of cyclopropanes under acidic conditions. The whole three-step sequence is conveniently performed in a one-pot mode.
摘要
描述了一种用 CF2 片段对酮进行同系化的方法。该反应涉及硅烷化、硅烯醇醚的室温二氟环丙烷化以及在酸性条件下环丙烷的选择性开环。整个三步序列可以方便地在一锅模式下进行。
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