光氧化还原催化的硅烯醇醚的硅基二氟甲基化反应。
Photoredox-catalyzed silyldifluoromethylation of silyl enol ethers.
作者信息
Supranovich Vyacheslav I, Levin Vitalij V, Dilman Alexander D
机构信息
N. D. Zelinsky Institute of Organic Chemistry, Leninsky prosp. 47, 119991 Moscow, Russian Federation.
出版信息
Beilstein J Org Chem. 2020 Jun 29;16:1550-1553. doi: 10.3762/bjoc.16.126. eCollection 2020.
A method for the light-mediated fluoroalkylation of silyl enol ethers with (bromodifluoromethyl)trimethylsilane followed by a reduction of the primary products with sodium borohydride is described. An 18 W, 375 nm LED was used as the light source. The reaction is performed in the presence of a gold photocatalyst, which effects the generation of a (trimethylsilyl)difluoromethyl radical via cleavage of the carbon-bromine bond.
描述了一种用光介导的硅烯醇醚与（溴二氟甲基）三甲基硅烷进行氟烷基化反应，随后用硼氢化钠还原初级产物的方法。使用一个18 W、375 nm的发光二极管作为光源。该反应在金光催化剂存在下进行，金光催化剂通过碳 - 溴键的裂解作用生成（三甲基硅基）二氟甲基自由基。
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