Maldonado Emma, Pérez-Castorena Ana L, Romero Yunuen, Martínez Mahinda
Instituto de Química, Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Coyoacán, 04510, D. F., México.
J Nat Prod. 2015 Feb 27;78(2):202-7. doi: 10.1021/np500688c. Epub 2015 Jan 29.
A mixture of the new epimeric labdenetriols 1 and 2 was isolated from the aerial parts of Physalis nicandroides. The structures of 1 and 2, including their absolute configurations, were established by analyses of their spectroscopic data, together with the X-ray diffraction analysis of acetonide 3 and chemical correlation with (-)-(13E)-labd-13-ene-8α,15-diol (6), whose absolute configuration was also confirmed by X-ray analysis of its dibromo derivative 7. The epimeric labdenediols 8 and 9, the known labdanes 6 and 11, and the acylsucroses 12 and 13 were also isolated. Labdanes 6 and 11 showed moderate anti-inflammatory activities in the induced ear edema model.
从酸浆属植物酸浆的地上部分分离出了新的差向异构半日花三醇1和2的混合物。通过对其光谱数据的分析，以及缩酮3的X射线衍射分析和与(-)-(13E)-赖百当-13-烯-8α,15-二醇(6)的化学关联，确定了1和2的结构，包括它们的绝对构型，其绝对构型也通过其二溴衍生物7的X射线分析得到证实。还分离出了差向异构赖百当二醇8和9、已知的赖百当类化合物6和11以及酰基蔗糖12和13。赖百当类化合物6和11在诱导耳水肿模型中表现出中等抗炎活性。
