Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá AA 14490, Colombia.
Bioorg Med Chem Lett. 2011 Oct 1;21(19):5888-91. doi: 10.1016/j.bmcl.2011.07.092. Epub 2011 Aug 4.
The screen of 10 soft coral extracts collected from the Colombian Caribbean Sea in the TPA-induced ear edema model allowed us to identify Eunicea fusca extract among others as an interesting source of active compounds. The new diterpene, fuscoside E (1), along with the known fuscoside B (2), fuscol (3), (+)-germacrene D (4) and a mixture of six sterols (5-10), were isolated from this soft coral. Their structures were elucidated by 1D and 2D NMR spectroscopy techniques. Fuscoside E (1) absolute stereochemistry was determined by chiroptical methods. Fuscoside E (1) and B (2) showed strong anti-inflammatory in the above mentioned bioassay. Additionally, fuscoside E (1) and the sterol mixture (5-10) presented antifouling activity against bacterial strains involved in surface colonization.
从哥伦比亚加勒比海采集的 10 种软珊瑚提取物在 TPA 诱导的耳肿胀模型中进行筛选，结果表明，其中的 Eunicella fusca 提取物是一种很有前途的活性化合物来源。从这种软珊瑚中分离得到了新的二萜类化合物 fuscoside E（1），以及已知的化合物 fuscoside B（2）、fuscol（3）、（+）-germacrene D（4）和六种甾醇的混合物（5-10）。其结构通过 1D 和 2D NMR 光谱技术进行了阐明。通过手性光学方法确定了 fuscoside E（1）的绝对立体化学。fuscoside E（1）和 B（2）在上述生物测定中表现出强烈的抗炎活性。此外，fuscoside E（1）和甾醇混合物（5-10）对参与表面定植的细菌菌株表现出抗生物污损活性。
