用于“对映选择性捕获”的磁性纯手性金属有机框架的简便合成
Facile synthesis of magnetic homochiral metal-organic frameworks for "enantioselective fishing".
作者信息
Chang Cui-Lan, Qi Xiao-Yue, Zhang Jiang-Wei, Qiu Ya-Ming, Li Xian-Jiang, Wang Xin, Bai Yu, Sun Jun-Liang, Liu Hu-Wei
机构信息
Beijing National Laboratory for Molecular Sciences, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
出版信息
Chem Commun (Camb). 2015 Feb 28;51(17):3566-9. doi: 10.1039/c4cc09988e.
Magnetic functionalized homochiral metal-organic frameworks (MOFs) were prepared and applied to efficient enantioselective fishing of chiral drug intermediates. Under optimized conditions, the enantiomeric excess (ee) value as high as 85.2% was achieved for methyl phenyl sulfoxide (MPS) within 3 min.
制备了磁性功能化的手性金属有机框架（MOF），并将其应用于高效对映选择性捕获手性药物中间体。在优化条件下，3分钟内苯基亚砜甲酯（MPS）的对映体过量（ee）值高达85.2%。
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