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Targeting PD1-PDL1 immune checkpoint in plasmacytoid dendritic cell interactions with T cells, natural killer cells and multiple myeloma cells.

作者信息

Ray A, Das D S, Song Y, Richardson P, Munshi N C, Chauhan D, Anderson K C

机构信息

The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

出版信息

Leukemia. 2015 Jun;29(6):1441-4. doi: 10.1038/leu.2015.11. Epub 2015 Jan 30.

DOI:10.1038/leu.2015.11
PMID:25634684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5703039/
Abstract
摘要

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Clin Cancer Res. 2014 Oct 1;20(19):5064-74. doi: 10.1158/1078-0432.CCR-13-3271. Epub 2014 Apr 8.
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A novel TLR-9 agonist C792 inhibits plasmacytoid dendritic cell-induced myeloma cell growth and enhance cytotoxicity of bortezomib.一种新型 TLR-9 激动剂 C792 抑制浆细胞样树突状细胞诱导的骨髓瘤细胞生长并增强硼替佐米的细胞毒性。
Leukemia. 2014 Aug;28(8):1716-24. doi: 10.1038/leu.2014.46. Epub 2014 Jan 30.
3
Coinhibitory molecule PD-1 as a potential target for the immunotherapy of multiple myeloma.
程序性细胞死亡配体-1在宫颈鳞状细胞癌中的表达及其与浸润、转移和预后的关系
Reprod Sci. 2025 May;32(5):1676-1684. doi: 10.1007/s43032-024-01784-5. Epub 2025 Jan 30.
4
From Biology to Clinical Practice: The Bone Marrow Microenvironment in Multiple Myeloma.从生物学至临床实践：多发性骨髓瘤中的骨髓微环境
J Clin Med. 2025 Jan 8;14(2):327. doi: 10.3390/jcm14020327.
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Bispecific antibody targets and therapies in multiple myeloma.双特异性抗体在多发性骨髓瘤中的靶点和治疗方法。
Front Immunol. 2024 Oct 10;15:1424925. doi: 10.3389/fimmu.2024.1424925. eCollection 2024.
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Advancements in microenvironment-based therapies: transforming the landscape of multiple myeloma treatment.基于微环境疗法的进展：改变多发性骨髓瘤的治疗格局
Front Oncol. 2024 Jul 17;14:1413494. doi: 10.3389/fonc.2024.1413494. eCollection 2024.
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抑制性分子 PD-1 作为多发性骨髓瘤免疫治疗的潜在靶点。
Leukemia. 2014 May;28(5):993-1000. doi: 10.1038/leu.2013.310. Epub 2013 Oct 23.
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New checkpoint inhibitors ride the immunotherapy tsunami.新型检查点抑制剂搭乘免疫疗法的浪潮。
Nat Rev Drug Discov. 2013 Jul;12(7):489-92. doi: 10.1038/nrd4066.
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Vaccination with dendritic cell/tumor fusions following autologous stem cell transplant induces immunologic and clinical responses in multiple myeloma patients.自体干细胞移植后用树突细胞/肿瘤融合细胞进行疫苗接种可诱导多发性骨髓瘤患者产生免疫和临床应答。
Clin Cancer Res. 2013 Jul 1;19(13):3640-8. doi: 10.1158/1078-0432.CCR-13-0282. Epub 2013 May 17.
6
Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma.短暂性淋巴清除后程序性死亡受体-1/程序性死亡受体配体-1 阻断治疗骨髓瘤。
J Immunol. 2013 Jun 1;190(11):5620-8. doi: 10.4049/jimmunol.1202005. Epub 2013 Apr 24.
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Marrow stromal cells induce B7-H1 expression on myeloma cells, generating aggressive characteristics in multiple myeloma.骨髓基质细胞诱导骨髓瘤细胞表达 B7-H1，从而在多发性骨髓瘤中产生侵袭性特征。
Leukemia. 2013 Feb;27(2):464-72. doi: 10.1038/leu.2012.213. Epub 2012 Jul 25.
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Sci Signal. 2012 Jun 26;5(230):ra46. doi: 10.1126/scisignal.2002796.
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The 39th David A. Karnofsky Lecture: bench-to-bedside translation of targeted therapies in multiple myeloma.第 39 届 David A. Karnofsky 讲座：多发性骨髓瘤靶向治疗的从基础到临床转化。
J Clin Oncol. 2012 Feb 1;30(4):445-52. doi: 10.1200/JCO.2011.37.8919. Epub 2012 Jan 3.
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