Lu Ke, Wang Wen, Liu Yuntong, Xie Chao, Liu Jiye, Xing Lijie
Department of Lymphoma, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States.
Front Oncol. 2024 Jul 17;14:1413494. doi: 10.3389/fonc.2024.1413494. eCollection 2024.
Multiple myeloma (MM) is the most prevalent malignant monoclonal disease of plasma cells. There is mounting evidence that interactions with the bone marrow (BM) niche are essential for the differentiation, proliferation, survival, migration, and treatment resistance of myeloma cells. For this reason, gaining a deeper comprehension of how BM microenvironment compartments interact with myeloma cells may inspire new therapeutic ideas that enhance patient outcomes. This review will concentrate on the most recent findings regarding the mechanisms of interaction between microenvironment and MM and highlight research on treatment targeting the BM niche.
多发性骨髓瘤（MM）是最常见的浆细胞恶性单克隆疾病。越来越多的证据表明，与骨髓（BM）微环境的相互作用对于骨髓瘤细胞的分化、增殖、存活、迁移和治疗耐药性至关重要。因此，更深入地了解BM微环境区室如何与骨髓瘤细胞相互作用，可能会激发新的治疗思路，从而改善患者预后。本综述将集中探讨关于微环境与MM相互作用机制的最新发现，并重点介绍针对BM微环境的治疗研究。
