21号染色体上阿尔茨海默病的易感基因座。

Predisposing locus for Alzheimer's disease on chromosome 21.

作者信息

Goate A M, Haynes A R, Owen M J, Farrall M, James L A, Lai L Y, Mullan M J, Roques P, Rossor M N, Williamson R

机构信息

Department of Biochemistry, St Mary's Hospital Medical School, London, England.

出版信息

Lancet. 1989 Feb 18;1(8634):352-5. doi: 10.1016/s0140-6736(89)91725-x.

DOI:10.1016/s0140-6736(89)91725-x

PMID:2563508

Abstract

Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that the data are consistent with the notion that all patients with Alzheimer's disease of genetic aetiology have a predisposing locus on chromosome 21.

摘要

在六个早发性阿尔茨海默病家族中，对21号染色体长臂上的标记与阿尔茨海默病之间的连锁关系进行了研究。连锁关系得到确认，且疾病位点显示位于染色体长臂上的D21S1/S11位点的着丝粒侧。有人认为，这些数据与所有具有遗传病因的阿尔茨海默病患者在21号染色体上都有一个易感位点的观点相一致。