Wijsman E M, Bird T D, Martin G M, Schellenberg G D
Division of Medical Genetics, University of Washington, Seattle 98195.
Genet Epidemiol. 1993;10(6):365-9. doi: 10.1002/gepi.1370100606.
Forty families submitted to Genetic Analysis Workshop 8 are described. These are the families in the Seattle data set which have been typed for at least one genetic marker from the centromeric region of chromosome 21 or the q arm of chromosome 19. Thirteen of these families have average ages of onset below age 61 and are therefore considered to be early onset families. Seven of the families are of Volga German descent. Thirty-four of the families have autopsy documented Alzheimer's disease, including all 13 of the early onset pedigrees. The data set includes both the clinical and pedigree information available on the portions of the pedigrees used in the linkage analyses, genotype data on three loci on chromosome 19 and four loci on chromosome 21, and more extended family data on individuals who have not been included in the linkage analyses.
本文描述了提交给遗传分析研讨会8的40个家族。这些家族来自西雅图数据集，它们至少针对21号染色体着丝粒区域或19号染色体长臂上的一个遗传标记进行了分型。其中13个家族的平均发病年龄低于61岁，因此被视为早发家族。7个家族有伏尔加德意志人血统。34个家族有尸检记录的阿尔茨海默病，包括所有13个早发谱系。该数据集包括连锁分析中使用的家系部分的临床和家系信息、19号染色体上三个位点和21号染色体上四个位点的基因型数据，以及未纳入连锁分析的个体的更广泛家族数据。
