Bailey-Wilson J E, Bamba V
Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans 70112.
Genet Epidemiol. 1993;10(6):371-6. doi: 10.1002/gepi.1370100607.
Sib-pair linkage analyses were used to search for linkage to a set of chromosome 19 and 21 marker loci in two sets of families with Alzheimer's disease. The advantage of this technique is that no assumption is made about the mode of inheritance of the disease. Some mild suggestions of linkage were found in early-onset families for a chromosome 21 marker and in a set of late-onset families for a chromosome 19 marker.
在两组患有阿尔茨海默病的家族中，采用同胞对连锁分析来寻找与19号和21号染色体上一组标记位点的连锁关系。该技术的优点是无需对疾病的遗传模式做出假设。在早发型家族中，发现了与一个21号染色体标记存在一些微弱的连锁迹象；在一组晚发型家族中，发现了与一个19号染色体标记存在微弱的连锁迹象。
