Kim Soo Young, Yang Hyun Suk, Lee Yang Won, Choe Yong Beom, Ahn Kyu Joong
Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.
Department of Cardiovascular Medicine, Konkuk University School of Medicine, Seoul, Korea.
Angiology. 2015 Oct;66(9):889-95. doi: 10.1177/0003319714568790. Epub 2015 Jan 29.
The risk of cardiovascular (CV) events is reportedly elevated in patients with psoriasis. Evaluation of the beta stiffness index (BSI) and carotid intima-media thickness (cIMT) are noninvasive methods of assessing arterial stiffness and subclinical atherosclerosis. We aimed to determine carotid arterial stiffness and cIMT, using high-resolution ultrasonography, in patients with psoriasis compared with controls, and to analyze whether psoriasis is an independent risk factor for atherosclerosis. A total of 54 consecutive patients with psoriasis and 60 age and gender-matched healthy controls were enrolled. Compared with control participants, patients with psoriasis exhibited a significantly higher BSI (P < .001). The cIMT tended to be higher in patients with psoriasis but statistically not significant (P = .076). BSI was positively correlated with age, systolic blood pressure, disease severity defined according to history of systemic treatment, and traditional CV risk factors. Also, psoriasis was independently associated with BSI. These findings suggest that psoriasis is an independent risk factor for arterial stiffness, and the BSI is an earlier indicator of atherosclerosis than cIMT in these patients.
据报道，银屑病患者发生心血管（CV）事件的风险会升高。评估β硬度指数（BSI）和颈动脉内膜中层厚度（cIMT）是评估动脉硬度和亚临床动脉粥样硬化的无创方法。我们旨在通过高分辨率超声检查确定银屑病患者与对照组相比的颈动脉硬度和cIMT，并分析银屑病是否为动脉粥样硬化的独立危险因素。总共纳入了54例连续的银屑病患者以及60例年龄和性别匹配的健康对照者。与对照参与者相比，银屑病患者的BSI显著更高（P <.001）。银屑病患者的cIMT往往更高，但在统计学上无显著差异（P = 0.076）。BSI与年龄、收缩压、根据全身治疗史定义的疾病严重程度以及传统CV危险因素呈正相关。此外，银屑病与BSI独立相关。这些发现表明，银屑病是动脉硬度的独立危险因素，并且在这些患者中，BSI是比cIMT更早的动脉粥样硬化指标。
