Weiss Ram, Nassar Hisham, Sinnreich Ronit, Kark Jeremy D
From the Hebrew University-Hadassah Braun School of Public Health and Community Medicine, Ein Kerem, Jerusalem, Israel.
St Joseph Hospital, East Jerusalem and Department of Cardiology, Hadassah University Medical Center, Ein Kerem, Jerusalem.
PLoS One. 2015 Jan 30;10(1):e0116617. doi: 10.1371/journal.pone.0116617. eCollection 2015.
To evaluate differences in the triglyceride to HDL-cholesterol ratio (TG/HDL), thought to be a proxy measure of insulin resistance, between Palestinian and Israeli adults in view of the greater incidence of coronary heart disease and high prevalence of diabetes in Palestinian Arabs.
A population-based observational prevalence study of cardiovascular and diabetes risk factors in Jerusalem. Participants (968 Palestinians, 707 Israelis, sampled at ages 25-74 years) underwent fasting and 2 h post-75 g oral challenge plasma glucose determinations. Metabolic risk was assessed using the surrogate index TG/HDL. Sex-specific comparisons were stratified by categories of body mass index and sex-specific waist circumference quartiles, adjusted by regression for age, glucose tolerance status and use of statins.
Prevalence of overweight and obesity was substantially larger in Palestinians (p = 0.005). Prevalence of diabetes was 2.4 and 4 fold higher among Palestinian men and women, respectively (p<0.001). Adjusted TG/HDL was higher in Palestinians than Israelis across BMI and waist circumference categories (p<0.001 for both). Higher TG/HDL in Palestinians persisted in analyses restricted to participants with normal glucose tolerance and off statins. Notably, higher TG/HDL among Palestinians prevailed at a young age (25-44 years) and in normal weight individuals of both sexes.
Palestinians have a higher TG/HDL ratio than Israelis. Notably, this is evident also in young, healthy and normal weight participants. These findings indicate the need to study the determinants of this biomarker and other measures of insulin resistance in urban Arab populations and to focus research attention on earlier ages: childhood and prenatal stages of development.
鉴于巴勒斯坦阿拉伯人冠心病发病率较高且糖尿病患病率较高，评估巴勒斯坦和以色列成年人之间甘油三酯与高密度脂蛋白胆固醇比值（TG/HDL）的差异，该比值被认为是胰岛素抵抗的替代指标。
一项基于人群的耶路撒冷心血管和糖尿病危险因素观察性患病率研究。参与者（968名巴勒斯坦人、707名以色列人，年龄在25 - 74岁之间）接受空腹及75克口服葡萄糖耐量试验后2小时的血浆葡萄糖测定。使用替代指标TG/HDL评估代谢风险。按体重指数类别和特定性别的腰围四分位数进行性别特异性比较，并通过年龄、葡萄糖耐量状态和他汀类药物使用情况的回归分析进行调整。
巴勒斯坦人的超重和肥胖患病率显著更高（p = 0.005）。巴勒斯坦男性和女性的糖尿病患病率分别高出2.4倍和4倍（p<0.001）。在BMI和腰围类别中，巴勒斯坦人的调整后TG/HDL均高于以色列人（两者p<0.001）。在仅限于葡萄糖耐量正常且未服用他汀类药物的参与者的分析中，巴勒斯坦人的TG/HDL仍然较高。值得注意的是，巴勒斯坦人较高的TG/HDL在年轻人群（25 - 44岁）以及男女正常体重个体中都存在。
巴勒斯坦人的TG/HDL比值高于以色列人。值得注意的是，这在年轻、健康和正常体重的参与者中也很明显。这些发现表明有必要研究城市阿拉伯人群中这种生物标志物和其他胰岛素抵抗指标的决定因素，并将研究重点放在更早的年龄段：儿童期和产前发育阶段。
