Graduate School of Pharmaceutical Sciences, Tohoku University , Aramaki Aza Aoba 6-3, Sendai 980-8578 Japan.
Org Lett. 2015 Feb 20;17(4):848-51. doi: 10.1021/ol503671b. Epub 2015 Jan 30.
A highly selective C-H silylation reaction of functionalized arenes and heteroarenes was developed using Ruppert-Prakash reagent (TMSCF3) activated by alkali metal fluoride. TMSCF3 is considered to play dual roles as a precursor of a mild base and also as a silicon electrophile. The silylation is compatible with sensitive functional groups such as halogen and nitro groups.
本文开发了一种使用碱金属氟化物激活的 Ruppert-Prakash 试剂（TMSCF3）对功能化芳烃和杂芳烃进行高选择性 C-H 硅烷化反应的方法。TMSCF3 被认为同时具有作为弱碱前体和硅亲电试剂的双重作用。该硅烷化反应与卤素和硝基等敏感官能团兼容。
