DNA模板化学文库的新型编码方法。
Novel encoding methods for DNA-templated chemical libraries.
作者信息
Li Gang, Zheng Wenlu, Liu Ying, Li Xiaoyu
机构信息
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, Beijing National Laboratory of Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
出版信息
Curr Opin Chem Biol. 2015 Jun;26:25-33. doi: 10.1016/j.cbpa.2015.01.004. Epub 2015 Jan 28.
Among various types of DNA-encoded chemical libraries, DNA-templated library takes advantage of the sequence-specificity of DNA hybridization, enabling not only highly effective DNA-templated chemical reactions, but also high fidelity in library encoding. This brief review summarizes recent advances that have been made on the encoding strategies for DNA-templated libraries, and it also highlights their respective advantages and limitations for the preparation of DNA-encoded libraries.
在各类DNA编码化学文库中，DNA模板文库利用了DNA杂交的序列特异性，不仅能够实现高效的DNA模板化学反应，还能在文库编码中保持高保真度。本简要综述总结了DNA模板文库编码策略的最新进展，并突出了它们在制备DNA编码文库方面各自的优势和局限性。
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