大唾液腺肌上皮癌的危险因素及预后
Risk Factors and Prognosis for Myoepithelial Carcinoma of the Major Salivary Glands.
作者信息
Su Yu-Xiong, Roberts Dianna B, Hanna Ehab Y, El-Naggar Adel, Saylam Güleser, Frank Steven J, Weber Randal S, Kupferman Michael E
机构信息
Discipline of Oral & Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, People's Republic of China.
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Ann Surg Oncol. 2015 Oct;22(11):3701-7. doi: 10.1245/s10434-015-4389-3. Epub 2015 Jan 31.
BACKGROUND
The clinical behavior and treatment outcomes of salivary gland myoepithelial carcinoma have yet to be clearly defined. The current study investigated risk factors and prognoses for this tumor.
METHODS
A retrospective review of the medical records for 32 patients with myoepithelial carcinoma of the major salivary glands was performed. Their clinical parameters were assessed to identify correlations with local-regional recurrence, distant metastasis, and survival.
RESULTS
The 5-year survival rate was 71 %. Of the reviewed patients, 41 % had local-regional recurrences, and 22 % had distant metastases. Age of 60 years or younger was a predictive factor for distant metastasis. Patients with neck lymph nodes clinically positive for carcinoma had shorter overall survival durations than those with nodes negative for carcinoma.
CONCLUSIONS
Myoepithelial carcinoma of the major salivary glands is characterized by a high incidence of local-regional recurrence and distant metastasis. Adjuvant therapy is indicated for selected patients with high-risk disease.
背景
涎腺肌上皮癌的临床行为和治疗结果尚未明确界定。本研究调查了该肿瘤的危险因素和预后情况。
方法
对32例大涎腺肌上皮癌患者的病历进行回顾性分析。评估他们的临床参数，以确定与局部区域复发、远处转移和生存的相关性。
结果
5年生存率为71%。在接受评估的患者中，41%发生局部区域复发，22%发生远处转移。60岁及以下年龄是远处转移的预测因素。颈部淋巴结临床检查呈癌阳性的患者总生存期短于淋巴结癌阴性的患者。
结论
大涎腺肌上皮癌的特点是局部区域复发和远处转移发生率高。对于选定的高危疾病患者，建议进行辅助治疗。
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