Durkin Maureen S, DuBois Lindsay A, Maenner Matthew J
Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, 789 WARF, 610 Walnut Street, Madison, WI, 53726, USA,
J Autism Dev Disord. 2015 Jul;45(7):2056-66. doi: 10.1007/s10803-015-2368-y.
Recent studies have reported an increased risk of autism among second-born children conceived <12 versus >36 months after the birth of a sibling. Confirmation of this finding would point to inter-pregnancy interval (IPI) as a potentially modifiable risk factor for autism. This study evaluated the relationship between IPI and autism spectrum disorder (ASD) risk in a Wisconsin birth cohort of 31,467 second-born children, of whom 160 resided in the study area and were found to have ASD at age 8 years. In adjusted analyses, both short (<12) and long (>84 month) IPIs were associated with a two-fold risk of ASD relative to IPIs of 24-47 months (p < 0.05). The long IPI association was partially confounded by history of previous pregnancy loss.
近期研究报告称，同胞出生后12个月内受孕的二胎儿童患自闭症的风险高于出生36个月后受孕的二胎儿童。这一发现若得到证实，将表明妊娠间隔（IPI）是自闭症一个潜在的可改变风险因素。本研究评估了威斯康星州31467名二胎儿童出生队列中IPI与自闭症谱系障碍（ASD）风险之间的关系，其中160名居住在研究区域，在8岁时被发现患有ASD。在调整分析中，与24 - 47个月的IPI相比，短（<12个月）和长（>84个月）IPI均与患ASD的两倍风险相关（p < 0.05）。长IPI的关联部分被既往流产史所混淆。
