Villiger Angela, Sala Filippo, Suter Andy, Butterweck Veronika
Institute for Pharma Technology, School of Life Sciences, University of Applied Sciences Northwestern Switzerland, Gründenstrasse 40, CH-4132 Muttenz, Switzerland.
Bioforce AG, Grünaustrasse 4, CH-9325 Roggwil, Switzerland.
Phytomedicine. 2015 Jan 15;22(1):138-44. doi: 10.1016/j.phymed.2014.11.015. Epub 2014 Nov 29.
Boldocynara®, a proprietary dietary supplement product consisting of the plants Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus, used to promote functions of the liver and the gallbladder. It was the aim of the present study to look from a different perspective at the product by investigating the in vitro potential of Boldocynara® as a combination product and its individual extracts on key enzymes relevant to metabolic syndrome. Peumus boldus extract exhibited pronounced inhibitory activities on α-glucosidase (80% inhibition at 100 µg/ml, IC50: 17.56 µg/ml). Silybum marianum had moderate pancreatic lipase (PL) inhibitory activities (30% at 100 µg/ml) whereas Cynara scolymus showed moderate ACE inhibitory activity (31% at 100 µg/ml). The combination had moderate to weak effects on the tested enzymes. In conclusion, our results indicate some moderate potential of the dietary supplement Boldocynara® and its single ingredients for the prevention of metabolic disorders.
宝多仙娜（Boldocynara®）是一种专利膳食补充剂产品，由洋蓟（Cynara scolymus）、水飞蓟（Silybum marianum）、蒲公英（Taraxacum officinale）和波尔多树（Peumus boldus）组成，用于促进肝脏和胆囊功能。本研究的目的是从不同角度研究宝多仙娜（Boldocynara®）作为一种组合产品及其单一提取物对与代谢综合征相关的关键酶的体外作用潜力。波尔多树提取物对α-葡萄糖苷酶表现出显著的抑制活性（在100μg/ml时抑制率为80%，IC50：17.56μg/ml）。水飞蓟对胰脂肪酶（PL）有中度抑制活性（在100μg/ml时为30%），而洋蓟表现出中度的血管紧张素转换酶（ACE）抑制活性（在100μg/ml时为31%）。该组合对所测试的酶有中度至微弱的作用。总之，我们的结果表明膳食补充剂宝多仙娜（Boldocynara®）及其单一成分在预防代谢紊乱方面有一定的中度潜力。
