Dembitsky Valery M, Gloriozova Tatyana A, Poroikov Vladimir V
Institute of Drug Discovery, P.O. Box 45289, Jerusalem 91451, Israel.
Institute of Biomedical Chemistry, Russian Academy of the Medical Sciences, Moscow 119121, Russia.
Phytomedicine. 2015 Jan 15;22(1):183-202. doi: 10.1016/j.phymed.2014.11.002. Epub 2014 Nov 20.
The present review describes research on novel natural isoquinoline alkaloids and their N-oxides isolated from different plant species. More than 200 biological active compounds have shown confirmed antimicrobial, antibacterial, antitumor, and other activities. The structures, origins, and reported biological activities of a selection of isoquinoline N-oxides alkaloids are reviewed. With the computer program PASS some additional SAR (structure-activity relationship) activities are also predicted, which point toward new possible applications of these compounds. This review emphasizes the role of isoquinoline N-oxides alkaloids as an important source of leads for drug discovery.
本综述描述了从不同植物物种中分离出的新型天然异喹啉生物碱及其N-氧化物的研究。200多种生物活性化合物已显示出具有抗菌、抗细菌、抗肿瘤和其他活性。本文综述了一些异喹啉N-氧化物生物碱的结构、来源及已报道的生物活性。利用计算机程序PASS还预测了一些额外的构效关系活性，这为这些化合物的新潜在应用指明了方向。本综述强调了异喹啉N-氧化物生物碱作为药物发现重要先导化合物来源的作用。
