Wu Y C, Liou Y F, Lu S T, Chen C H, Chang J J, Lee K H
Planta Med. 1989 Apr;55(2):163-5. doi: 10.1055/s-2006-961913.
A series of 53 isoquinoline alkaloids and their N-oxides have been tested for their cytotoxicity against A-549, HCT-8, KB, P-388, and L-1210 cells. These alkaloids include two tetrahydroprotoberberines, two protoberberines, six aporphines, one morphinandienone, five oxoaporphines, seven phenanthrenes, one spirobenzylisoquinoline N-oxide, nine aporphine N-oxides, seven benzyltetrahydroisoquinoline N-oxides, one benzylisoquinoline N-oxide, one protopine N-oxide, three tetrahydroprotoberberine N-oxides, four pavine N-oxides, and four phenanthrene N-oxides. The results are discussed on the basis of structure-activity relationships.
已对一系列53种异喹啉生物碱及其N-氧化物针对A-549、HCT-8、KB、P-388和L-1210细胞的细胞毒性进行了测试。这些生物碱包括两种四氢原小檗碱、两种原小檗碱、六种阿朴啡、一种吗啡二烯酮、五种氧化阿朴啡、七种菲、一种螺苄基异喹啉N-氧化物、九种阿朴啡N-氧化物、七种苄基四氢异喹啉N-氧化物、一种苄基异喹啉N-氧化物、一种原托品N-氧化物、三种四氢原小檗碱N-氧化物、四种巴豆碱N-氧化物和四种菲N-氧化物。根据构效关系对结果进行了讨论。
