Wang Litao, Dong Shuqing, Han Feng, Zhao Yingwei, Zhang Xia, Zhang Xiaoli, Qiu Hongdeng, Zhao Liang
Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China.
Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China; University of Chinese Academy of Sciences, Beijing 100039, PR China.
J Chromatogr A. 2015 Feb 27;1383:70-8. doi: 10.1016/j.chroma.2015.01.023. Epub 2015 Jan 15.
Spherical β-CD-silica hybrid materials have been prepared successfully by simple one-pot polymerization, which provide a new strategy to construct new type of HPLC chiral stationary phases. Various β-CD, ethane, triazinyl and 3,5-dimethylphenyl functional groups that can provide multiple interactions were introduced into the pore channels and pore wall framework of mesoporous materials, respectively. The materials towards some chiral, acidic, anilines and phenols compounds showed multiple chromatographic separation functions including racemic resolution, anion exchange and achiral separations with a typical feature of normal/reversed phase chromatography. Multi-tasking including racemic resolution and achiral separations for selected compounds were performed simultaneously on a chiral chromatographic column. The multifunctional character of materials arises from the multiple interactions including hydrophobic interaction, π-π interaction, anion exchange, inclusion interaction and hydrogen bonding interaction.
通过简单的一锅法聚合成功制备了球形β-环糊精-二氧化硅杂化材料，这为构建新型高效液相色谱手性固定相提供了一种新策略。分别将各种能够提供多种相互作用的β-环糊精、乙烷、三嗪基和3,5-二甲基苯基官能团引入到介孔材料的孔道和孔壁骨架中。该材料对一些手性、酸性、苯胺和酚类化合物表现出多种色谱分离功能，包括外消旋体拆分、阴离子交换和非手性分离，具有正/反相色谱的典型特征。在一个手性色谱柱上同时对选定化合物进行了包括外消旋体拆分和非手性分离在内的多任务操作。材料的多功能特性源于疏水相互作用、π-π相互作用、阴离子交换、包合相互作用和氢键相互作用等多种相互作用。
