Lai Xiang-Hua, Ng Siu-Choon
Department of Chemistry, National University of Singapore, Singapore 119260, Singapore.
J Chromatogr A. 2004 Mar 26;1031(1-2):135-42. doi: 10.1016/j.chroma.2003.11.018.
A novel chiral stationary phase (CSP) was prepared by immobilizing mono(6A-N-allylamino-6A-deoxy)-perphenylcarbamoylated beta-cyclodextrin onto the surface of silica gel via hydrosilylation. The chromatographic properties of this column were tested with a wide range of structurally diverse racemic compounds and drugs under reverse phases. Separation mechanisms involved are also discussed.
通过硅氢加成反应将单（6A-N-烯丙基氨基-6A-脱氧）-全苯基氨基甲酰化β-环糊精固定在硅胶表面，制备了一种新型手性固定相（CSP）。在反相条件下，用多种结构不同的外消旋化合物和药物对该柱的色谱性能进行了测试。还讨论了所涉及的分离机制。
