Fujita Yasuko, Kishimoto Mitsuo, Nakao Ryuta, Kimura-Tsuchiya Reiko, Yagi Nobuaki, Yanagisawa Akio
Department of Pathology, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto-shi, Kyoto, 602-8566, Japan.
Department of Surgical Pathology, Japanese Red Cross Society Kyoto Daiichi Hospital, Kyoto, Japan.
Gastric Cancer. 2016 Jan;19(1):192-7. doi: 10.1007/s10120-015-0465-4. Epub 2015 Feb 1.
Lymphatic involvement may sometimes be detected in differentiated-type intramucosal cancer resected endoscopically during routine examination, but its incidence and clinical significance remain unknown.
We examined 300 endoscopically resected lesions obtained from 238 patients diagnosed with differentiated-type intramucosal gastric cancer. All sections were subjected to D2-40 monoclonal-based immunohistochemistry.
The incidence of lymphatic involvement in differentiated-type intramucosal cancer was 2.0% (6/300). An incidence of 1.8% (5/279) was determined in lesions that were ≤ 3 cm in size and 2.2% (6/276) in those without an ulcer or ulcer scar. Of the six lesions presenting lymphatic involvement, three were determined to be histologically mixed with a predominance of differentiated type, while the other three lesions were pure differentiated type.
We determined that the incidence of lymphatic involvement in differentiated-type intramucosal cancer was 2.0%. To clarify the clinical significance of such lymphatic involvement, it is necessary to detect it with this incidence in mind and to gather and follow up the clinical courses of such cases.
在常规检查中，内镜切除的分化型黏膜内癌有时可检测到淋巴管受累，但其发生率及临床意义尚不清楚。
我们检查了238例诊断为分化型胃黏膜内癌患者的300个内镜切除病变。所有切片均进行基于D2-40单克隆抗体的免疫组织化学检测。
分化型黏膜内癌的淋巴管受累发生率为2.0%（6/300）。大小≤3 cm的病变中发生率为1.8%（5/279），无溃疡或溃疡瘢痕的病变中发生率为2.2%（6/276）。在出现淋巴管受累的6个病变中，3个在组织学上为混合性，以分化型为主，另外3个病变为纯分化型。
我们确定分化型黏膜内癌的淋巴管受累发生率为2.0%。为阐明这种淋巴管受累的临床意义，有必要在考虑到这一发生率的情况下对其进行检测，并收集和随访此类病例的临床病程。
