Neto Walter Krause, Gama Eliane Florencio, Rocha Leandro Yanase, Ramos Carla Cristina, Taets Wagner, Scapini Katia Bilhar, Ferreira Janaina B, Rodrigues Bruno, Caperuto Érico
Laboratory of Morphoquantitative Studies and Immunohistochemistry, Department of Physical Education, São Judas Tadeu University, São Paulo, SP, Brazil,
Age (Dordr). 2015 Feb;37(1):9742. doi: 10.1007/s11357-014-9742-0. Epub 2015 Feb 1.
The objective of this study was to evaluate the effects of steroid anabolic androgenic hormones use on lean mass gain in elderly men through a systematic review with a meta-analysis of randomized controlled studies. We systematically searched PubMed database until 4th October 2013. We included randomized placebo-controlled trials (RCT) that studied testosterone replacement therapy in men over 60 years of age, with total testosterone levels ≤550 ng/dl, observing gains in weight, lean mass tissue and fat mass as outcome. We excluded duplicated studies, studies which mixed men and women, and studies using weak androgens such as dehydroepiandrosterone or androstenedione. The initial search yielded 2681 articles, of which 26 were selected for full text analysis. In the end, 11 studies were included. However, 3 studies were not included in the meta-analysis. Meta-analysis showed that mean weight increased (lean mass), ranging from 1.65 (95 % CI, 1.61-1.69) to 6.20 (95 % CI, 5.22-7.18) kg, although it was heterogeneous (I (2) = 98 %). Effect estimate was 3.59 [2.38-4.81]. Androgen therapy decreased fat mass; effect estimate was -1.78 [-2.57, -0.99] that analysis had also a high level of heterogeneity (I (2) = 81 %). The results suggest that testosterone replacement therapy is able to increase muscle mass in elderly men and that is affected by the time that the treatment is carried out and the method of administration of the drug.
本研究的目的是通过对随机对照研究进行系统评价和荟萃分析，评估使用类固醇合成代谢雄激素对老年男性瘦体重增加的影响。我们系统检索了截至2013年10月4日的PubMed数据库。我们纳入了随机安慰剂对照试验（RCT），这些试验研究了60岁以上、总睾酮水平≤550 ng/dl男性的睾酮替代疗法，并观察体重、瘦体重组织和脂肪量的增加作为结局。我们排除了重复研究、混合了男性和女性的研究，以及使用脱氢表雄酮或雄烯二酮等弱雄激素的研究。初步检索得到2681篇文章，其中26篇被选作全文分析。最终，纳入了11项研究。然而，3项研究未纳入荟萃分析。荟萃分析显示，平均体重增加（瘦体重），范围从1.65（95%CI，1.61 - 1.69）至6.20（95%CI，5.22 - 7.18）kg，尽管存在异质性（I(2)=98%）。效应估计值为3.59[2.38 - 4.81]。雄激素治疗减少了脂肪量；效应估计值为 - 1.78[-2.57，-0.99]，该分析也具有高度异质性（I(2)=81%）。结果表明，睾酮替代疗法能够增加老年男性的肌肉量，且这受治疗实施时间和药物给药方法的影响。
