Oh Ki Won, Moon Chang Hoon, Lee Kyung Yeon
Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
J Child Neurol. 2015 Oct;30(11):1433-9. doi: 10.1177/0883073814568153. Epub 2015 Jan 30.
We aimed to identify whether rotavirus, human parechovirus, or enterovirus are causative or associated viral pathogens of seizures accompanied by diffuse cerebral white matter injury in neonates. Thirty neonates who presented with seizures and diffusion-restriction in the widespread bilateral cerebral white matter on diffusion-weighted magnetic resonance imaging (MRI) were included in this study. All patients were tested for rotavirus, human parechovirus, and enterovirus by using reverse transcription PCR. Stool, cerebrospinal fluid, and serum samples were examined in 30, 25, and 20 patients, respectively. Rotavirus was detected in stool samples from all 30 patients (100%). Stool samples from 5 patients (16.7%) were also positive for enterovirus. Rotavirus or human parechovirus were not detected in any cerebrospinal fluid samples from 25 patients, but 1 patient tested positive for enterovirus. No virus was detected in any of 20 patient sera. This study indicated an association between rotavirus and seizures accompanied by diffuse cerebral white matter lesions in neonates.
我们旨在确定轮状病毒、人细小病毒或肠道病毒是否为新生儿癫痫伴弥漫性脑白质损伤的致病或相关病毒病原体。本研究纳入了30例在扩散加权磁共振成像（MRI）上出现癫痫发作且双侧广泛脑白质存在扩散受限的新生儿。所有患者均采用逆转录聚合酶链反应检测轮状病毒、人细小病毒和肠道病毒。分别对30例、25例和20例患者的粪便、脑脊液和血清样本进行了检测。所有30例患者（100%）的粪便样本中均检测到轮状病毒。5例患者（16.7%）的粪便样本中肠道病毒也呈阳性。25例患者的任何脑脊液样本中均未检测到轮状病毒或人细小病毒，但有1例患者肠道病毒检测呈阳性。20例患者的血清中均未检测到病毒。本研究表明轮状病毒与新生儿癫痫伴弥漫性脑白质病变之间存在关联。
