Lyakhova Ekaterina G, Kolesnikova Sophia A, Kalinovsky Anatoly I, Dmitrenok Pavel S, Nam Nguyen H, Stonik Valentin A
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
Steroids. 2015 Apr;96:37-43. doi: 10.1016/j.steroids.2015.01.009. Epub 2015 Jan 29.
Eight new oxidized lanostane and nor-lanostane derivatives (1-8) along with the previously known penasterol (9) and 24-ethylcholesta-4,24(28)-dien-3-one (10) were isolated from a sponge Penares sp. collected from the Vietnamese waters. Structures of these minor compounds were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses and by comparison with earlier reported spectroscopic data. A hypothetic scheme of metabolism of the lanostane derivatives in sponges belonging to Penares and Erylus genera was proposed and discussed.
从采集于越南海域的一种海绵Penares sp.中分离出8种新的氧化羊毛甾烷和去甲羊毛甾烷衍生物（1-8），以及先前已知的海绵甾醇（9）和24-乙基胆甾-4,24(28)-二烯-3-酮（10）。通过详细的核磁共振光谱和质谱分析，并与早期报道的光谱数据进行比较，阐明了这些次要化合物的结构。提出并讨论了属于Penares属和Erylus属海绵中羊毛甾烷衍生物的代谢假说方案。
