Koivumäki Tuomas, Teuho Jarmo, Teräs Mika, Vauhkonen Marko, Hakulinen Mikko A
Diagnostic Imaging Centre, Kuopio University Hospital, Kuopio, Finland,
Ann Nucl Med. 2015 May;29(4):351-8. doi: 10.1007/s12149-015-0953-y. Epub 2015 Feb 1.
Respiratory motion causes loss of image quality and inaccuracy of quantification in oncologic positron emission tomography (PET) imaging. This study introduces a bioimpedance-based gating method for compensation of respiratory motion artefacts.
The bioimpedance-based respiratory gating method was studied parallel to a clinically used respiratory gating method [Real-time Position Management by Varian Medical Systems] in 4D PET/CT acquisition of 9 oncologic patients. The quantitative analysis consisted of the evaluation of tumour SUVpeak, SUVmax and volume. Additionally, target-to-background ratios as well as motion in cranial-caudal and anterior-posterior directions were measured. The evaluation was performed with amplitude- and time-based gating using averaged attenuation correction maps.
Bioimpedance gating resulted in 17.7-18.9 % increase in mean SUVpeak and 20.0-21.4 % decrease in mean volume compared to non-gated images. The maximum motion measured from the bioimpedance-gated images was 19 mm in cranial-caudal direction and 9 mm in anterior-posterior direction.
Bioimpedance-based respiratory gating compensates the adverse effects of motion in oncologic PET imaging.
呼吸运动导致肿瘤正电子发射断层扫描（PET）成像中图像质量下降和定量不准确。本研究引入了一种基于生物阻抗的门控方法来补偿呼吸运动伪影。
在9例肿瘤患者的4D PET/CT采集中，将基于生物阻抗的呼吸门控方法与临床使用的呼吸门控方法[瓦里安医疗系统公司的实时位置管理]并行研究。定量分析包括对肿瘤SUVpeak、SUVmax和体积的评估。此外，还测量了靶本底比以及头足和前后方向的运动。使用平均衰减校正图，基于幅度和时间的门控进行评估。
与非门控图像相比，生物阻抗门控使平均SUVpeak增加了17.7 - 18.9%，平均体积减少了20.0 - 21.4%。从生物阻抗门控图像测量的最大运动在头足方向为19毫米，在前后方向为9毫米。
基于生物阻抗的呼吸门控可补偿肿瘤PET成像中运动的不利影响。
