Department of Applied Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.
Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland.
J Nucl Cardiol. 2018 Oct;25(5):1633-1641. doi: 10.1007/s12350-017-0844-9. Epub 2017 Mar 16.
Respiratory motion (RM) complicates the analysis of myocardial perfusion (MP) single-photon emission computed tomography (SPECT) images. The effects of RM on left ventricular (LV) functional variables have not been thoroughly investigated.
Thoracic electrical bioimpedance and electrocardiographic signals were recorded from eighteen patients undergoing the rest phase of a 1-day stress/rest cardiac-gated MP-SPECT examination. The signals and list-mode emission data were retrospectively processed to yield standard cardiac- and dual-gated (respiratory and cardiac gating) image sets applying a novel algorithm. LV volume, MP, shape index (SI), wall motion (WM), wall thickening (WT), and phase analysis parameters were measured with Quantitative Perfusion SPECT/Quantitative Gated SPECT software (Cedars-Sinai Medical Center). Image quality was evaluated by three experienced physicians. Dual gating increased LV volume (77.1 ± 26.8 vs 79.8 ± 27.6 mL, P = .006) and decreased SI (0.57 ± 0.05 vs 0.56 ± 0.05, P = .036) and global WT (39.0 ± 11.8% vs 36.9 ± 9.4%, P = .034) compared to cardiac gating, but did not significantly alter perfusion, WM or phase analysis parameters or image quality (P > .05).
RM reduction has an effect on LV volume, shape, and WT parameters. RM exerts no significant effect on phase analysis parameters.
呼吸运动（RM）会使心肌灌注（MP）单光子发射计算机断层扫描（SPECT）图像的分析变得复杂。RM 对左心室（LV）功能变量的影响尚未得到彻底研究。
18 名接受为期一天的应激/静息心脏门控 MP-SPECT 检查的患者，从他们的胸部记录电生物阻抗和心电图信号。使用一种新算法，对信号和列表模式发射数据进行回顾性处理，以生成标准的心脏和双门控（呼吸门控和心脏门控）图像集。使用定量灌注 SPECT/定量门控 SPECT 软件（西达赛奈医疗中心）测量 LV 容积、MP、形状指数（SI）、壁运动（WM）、壁增厚（WT）和相位分析参数。三位有经验的医生评估图像质量。与心脏门控相比，双门控增加了 LV 容积（77.1 ± 26.8 比 79.8 ± 27.6 mL，P = 0.006），降低了 SI（0.57 ± 0.05 比 0.56 ± 0.05，P = 0.036）和整体 WT（39.0 ± 11.8% 比 36.9 ± 9.4%，P = 0.034），但对灌注、WM 或相位分析参数或图像质量没有显著影响（P > 0.05）。
RM 减少对 LV 容积、形状和 WT 参数有影响。RM 对相位分析参数没有显著影响。
