Nosanchuk J S, D'Souza J P, Mudholkar G S, Lin C C, Verno M, Buchanan B
Arch Pathol Lab Med. 1978 May;102(5):258-62.
A comparative study of five competitive commercial reagents for the Coulter Model S was performed jointly by two large, busy hospital laboratories with active quality control programs. Both laboratories, independently using the same reagent systems, studied 20 consecutive blood samples from patients from their own respective hospital for 20 days. Data from both laboratories were analyzed by standard and nonstandard statistical methods, and the results from both laboratories were compared. Although all reagent systems performed reasonably well in a clinical setting, highly significant statistical differences in their precisions were demonstrated by using univariate and multivariate techniques. The statistical method developed in this study can be applied to other systematic investigations that compare reagent systems.
两个大型繁忙的医院实验室联合开展了一项针对库尔特S型血细胞计数仪的五种竞争性商用试剂的对比研究，这两个实验室都有活跃的质量控制项目。两个实验室各自独立使用相同的试剂系统，对来自各自医院的20名患者的连续20份血样进行了研究。两个实验室的数据均采用标准和非标准统计方法进行分析，并对两个实验室的结果进行了比较。尽管所有试剂系统在临床环境中表现都还算不错，但通过单变量和多变量技术显示，它们在精密度方面存在高度显著的统计学差异。本研究中开发的统计方法可应用于其他比较试剂系统的系统调查。
