Swanson Christine M, Shea Steven A, Stone Katie L, Cauley Jane A, Rosen Clifford J, Redline Susan, Karsenty Gerard, Orwoll Eric S
Division of Endocrinology, Oregon Health and Science University, Portland, OR, USA; Bone and Mineral Unit, Oregon Health and Science University, Portland, OR, USA.
J Bone Miner Res. 2015 Feb;30(2):199-211. doi: 10.1002/jbmr.2446.
Obstructive sleep apnea (OSA) and low bone mass are two prevalent conditions, particularly among older adults-a section of the U.S. population that is expected to grow dramatically over the coming years. OSA, the most common form of sleep-disordered breathing, has been linked to multiple cardiovascular, metabolic, hormonal, and inflammatory derangements and may have adverse effects on bone. However, little is known about how OSA (including the associated hypoxia and sleep loss) affects bone metabolism. In order to gain insight into the relationship between sleep and bone, we review the growing information on OSA and metabolic bone disease and discuss the pathophysiological mechanisms by which OSA may affect bone metabolism/architecture.
阻塞性睡眠呼吸暂停（OSA）和低骨量是两种常见病症，在老年人中尤为普遍——美国的这部分人口预计在未来几年将大幅增长。OSA是睡眠呼吸障碍最常见的形式，与多种心血管、代谢、激素和炎症紊乱有关，可能对骨骼产生不利影响。然而，关于OSA（包括相关的缺氧和睡眠不足）如何影响骨代谢知之甚少。为了深入了解睡眠与骨骼之间的关系，我们回顾了关于OSA和代谢性骨病的越来越多的信息，并讨论了OSA可能影响骨代谢/结构的病理生理机制。
