Rostamzadeh Farzaneh, Joukar Siyavash, Yeganeh-Hajahmadi Mahboobeh
Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
Department of Physiology and Pharmacology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
NPJ Aging. 2024 Oct 2;10(1):43. doi: 10.1038/s41514-024-00165-1.
The prevalence of sleep disorders has been reported from 1.6% to 56.0%, worldwide. Sleep deprivation causes cardiovascular diseases (CVDs) including atherosclerosis, vascular aging, hypertension, heart dysfunction, reduced heart rate variability, and cardiac arrhythmia. Reduced tissue oxygen causes various CVDs by activating pro-inflammatory factors and increasing oxidative stress. Sleep disorders are more important and prevalent in older people and cause more severe cardiovascular complications. On the other hand, the reduction of Klotho level, an age-dependent protein whose expression decreases with age, is associated with age-related diseases. Sirtuins, class III histone deacetylases, also are among the essential factors in postponing cellular aging and increasing the lifespan of organisms, and they do this by regulating different pathways in the cell. Sirtuins and Klotho play an important role in the pathophysiology of CVDS and both have anti-oxidative stress and anti-inflammatory activity. Studies have shown that the levels of Klotho and sirtuins are altered in sleep disorders. In this article, alterations of Klotho and sirtuins in sleep disorders and in the development of sleep-related CVDs were reviewed and the possible signaling pathways were discussed. The inclusion criteria were studies with keywords of different types of sleep disorders and CVDs, klotho, SIRT1-7, and sirtuins in PubMed, Scopus, Embase، Science Direct، Web of Sciences and Google Scholar by the end of 2023. The studies revealed there is a bidirectional relationship between sleep disorders and the serum and tissue levels of Klotho and sirtuins and sleep related-CVDs.
据报道，全球睡眠障碍的患病率在1.6%至56.0%之间。睡眠剥夺会引发心血管疾病（CVDs），包括动脉粥样硬化、血管老化、高血压、心脏功能障碍、心率变异性降低和心律失常。组织氧含量降低通过激活促炎因子和增加氧化应激导致各种心血管疾病。睡眠障碍在老年人中更为重要和普遍，并会引发更严重的心血管并发症。另一方面，Klotho水平的降低与年龄相关疾病有关，Klotho是一种随年龄增长而表达下降的年龄依赖性蛋白质。Sirtuins是III类组蛋白脱乙酰酶，也是延缓细胞衰老和延长生物体寿命的重要因素之一，它们通过调节细胞内的不同途径来实现这一点。Sirtuins和Klotho在心血管疾病的病理生理学中发挥着重要作用，两者都具有抗氧化应激和抗炎活性。研究表明，睡眠障碍会改变Klotho和Sirtuins的水平。本文综述了睡眠障碍以及与睡眠相关的心血管疾病发生过程中Klotho和Sirtuins的变化，并探讨了可能的信号通路。纳入标准为截至2023年底在PubMed、Scopus、Embase、Science Direct、Web of Sciences和Google Scholar上检索到的有关不同类型睡眠障碍和心血管疾病、Klotho、SIRT1 - 7以及Sirtuins的关键词研究。这些研究表明，睡眠障碍与Klotho和Sirtuins的血清及组织水平以及与睡眠相关的心血管疾病之间存在双向关系。
