Panitz S, Kornhuber M, Hanisch F
Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle, Saale, Germany.
Acta Neurol Scand. 2015 Jun;131(6):372-80. doi: 10.1111/ane.12349. Epub 2015 Jan 7.
Fatigue may be underestimated symptom in amyotrophic lateral sclerosis (ALS). The self-administered checklist individual strength (CIS20-R) was used to measure both physical and mental fatigue in ALS.
Fatigue was measured in 51 consecutive patients with ALS using the fatigue severity scale (FSS) and the CIS20-R (four dimensions: subjective fatigue experience, concentration, motivation, activity). The questionnaire scores were compared with disease and progression parameters [revised ALS functional rating scale (ALS-FRS-R), MRC sum score, slow vital capacity (slow VC)]. Patients had follow-ups at six and 12 months.
At baseline (mean age: 57.9 years ± 12.3, mean disease duration: 15.8 months ± 12.7) clinical relevant fatigue was seen in 49% in FSS and 40% in CIS20-R. FSS and CIS20-R (except the subscale for concentration) were steadily increasing in the course of the disease. CIS1 (subjective fatigue) but not FSS showed a correlation to the ALS-FRS-R and the progression of the ALS-FRS-R after 12 months. There was a moderate positive correlation between FSS and CIS20-R.
The CIS20-R is a sensitive tool to detect clinically relevant fatigue in early stages of ALS. Both physical and mental (motivation) dimensions of fatigue steadily increase during the course of the disease in ALS.
疲劳可能是肌萎缩侧索硬化症（ALS）中被低估的症状。自我管理的个人力量清单（CIS20-R）用于测量ALS患者的身体和精神疲劳。
使用疲劳严重程度量表（FSS）和CIS20-R（四个维度：主观疲劳体验、注意力、动机、活动）对51例连续的ALS患者进行疲劳测量。将问卷得分与疾病和进展参数[修订的ALS功能评定量表（ALS-FRS-R）、医学研究委员会（MRC）总分、慢肺活量（slow VC）]进行比较。患者在6个月和12个月时进行随访。
基线时（平均年龄：57.9岁±12.3，平均病程：15.8个月±12.7），FSS中49%的患者以及CIS20-R中40%的患者出现临床相关疲劳。在疾病过程中，FSS和CIS20-R（注意力子量表除外）持续增加。CIS1（主观疲劳）与ALS-FRS-R以及12个月后ALS-FRS-R的进展相关，而FSS则无此关联。FSS与CIS20-R之间存在中度正相关。
CIS20-R是检测ALS早期临床相关疲劳的敏感工具。在ALS疾病过程中，疲劳的身体和精神（动机）维度均持续增加。
