Universidade Federal de Minas Gerais, Departamento de Fisioterapia, Belo Horizonte MG, Brazil.
Universidade Federal de Minas Gerais, Programa de Pós-Graduação em Neurociência, Belo Horizonte MG, Brazil.
Arq Neuropsiquiatr. 2022 Oct;80(10):1045-1051. doi: 10.1055/s-0042-1758563. Epub 2022 Dec 19.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that leads to muscle weakness and paralysis. Fatigue is a disabling symptom, frequently reported in ALS, but remains under-investigated in this population. Thus, an accurate investigation of this symptom and possible associated factors in this clinical condition is needed to assist in the establishment of an adequate treatment approach.
To investigate the presence of fatigue in individuals with ALS and possible factors correlated with this symptom.
Sixty-five individuals with sporadic ALS participated in the present study. Demographic, clinical, and functional aspects were investigated. Evaluations involved the Fatigue Severity Scale (FSS), ALS Functional Scale (ALSRFS-R), and Quality of Life (QoL) questionnaire (ALSAQ-40). Descriptive and correlation analyses were performed with SPSS statistical program for Windows version 19.0 (IBM Corp., Armonk, NY, USA).
Among the 65 individuals evaluated, 44.6% ( = 29) presented fatigue based on the FSS. The mean fatigue intensity was 5.4 ± 1.2 and only 10.4% used a specific medication for fatigue. Differences between the groups with and without fatigue were found regarding sex ( = 0.049), pain intensity ( = 0.026), functioning ( = 0.004), disease severity ( = 0.029), and QoL ( = 0.000). Fatigue was correlated with pain intensity (r = 0.425; = 0.001), muscle strength (r = - 0.356; = 0.004), functioning (r = - 0.363; = 0.003), and QoL (r = 0.481; = 0.000). No correlations were found with age, time since diagnosis, cramps, or other mobility parameters.
Fatigue is a common symptom among individuals with ALS and may be present in all stages of the disease. This symptom was correlated with worse functioning, poorer QoL, greater pain intensity, disease severity, muscle weakness, and the female sex in individuals with ALS.
肌萎缩侧索硬化症（ALS）是一种致命的神经退行性疾病，可导致肌肉无力和瘫痪。疲劳是 ALS 的一种致残症状，在该人群中经常报告，但对此症状的研究仍不够充分。因此，需要对该症状和可能与之相关的因素进行准确的调查，以协助制定适当的治疗方法。
研究肌萎缩侧索硬化症患者的疲劳症状及其与可能相关的因素。
本研究共纳入 65 名散发型 ALS 患者。对其进行人口统计学、临床和功能方面的评估。评估内容包括疲劳严重程度量表（FSS）、肌萎缩侧索硬化功能量表修订版（ALSRFS-R）和生活质量问卷（ALSAQ-40）。采用 SPSS 统计软件进行描述性和相关性分析，版本为 19.0（IBM 公司，美国纽约州阿蒙克市）。
在 65 名评估者中，44.6%（29 名）根据 FSS 出现疲劳症状。平均疲劳强度为 5.4±1.2，仅有 10.4%的患者使用特定药物治疗疲劳。有和无疲劳症状的两组之间在性别（ = 0.049）、疼痛强度（ = 0.026）、功能（ = 0.004）、疾病严重程度（ = 0.029）和生活质量（ = 0.000）方面存在差异。疲劳与疼痛强度（r = 0.425； = 0.001）、肌肉力量（r = - 0.356； = 0.004）、功能（r = - 0.363； = 0.003）和生活质量（r = 0.481； = 0.000）相关。但与年龄、诊断后时间、痉挛或其他运动参数均无相关性。
疲劳是 ALS 患者的常见症状，可能出现在疾病的各个阶段。该症状与功能较差、生活质量较差、疼痛强度较大、疾病严重程度较高、肌肉无力和女性性别有关。
