Nemes-Nikodém Éva, Brunner Alexandra, Tóth Béla, Tóth Veronika, Bánvölgyi András, Ostorházi Eszter
Semmelweis Egyetem, Általános Orvostudományi Kar Bőr-, Nemikórtani és Bőronkológiai Klinika Budapest Mária u. 41. 1085.
Orv Hetil. 2015 Feb 8;156(6):226-9. doi: 10.1556/OH.2015.30079.
European guidelines on the treatment of Neisseria gonorrhoeae are based mostly on Western European data, although these recommendations may not be optimised for the circumstances in Hungary.
The aim of the authors was to assess current antimicrobial resistance of Neisseria gonorrhoeae strains in order to enhance gonococcal antimicrobial surveillance in Hungary. Neisseria gonorrhoeae strains were isolated at the National Center of Sexually Transmitted Infections at the Department of Dermatology, Venerology and Dermatooncology of Semmelweis University in the period between January 2011 and June 2014.
Antimicrobial resistance was determined with minimum inhibitory concentration measurement. Neisseria gonorrhoeae Multiantigen Sequence typing was used as molecular typing method.
Resistance to the currently recommended extended spectrum cephalosporins is rare in Hungary, but there is an emerging azithromycin resistance among the Neisseria gonorrhoeae strains.
Revision of the national treatment guideline must consider that the most frequent sequence types of Neisseria gonorrhoeae strains causing infections in Hungary are mainly resistant to azithromycin.
欧洲关于淋病奈瑟菌治疗的指南主要基于西欧数据，尽管这些建议可能并未针对匈牙利的情况进行优化。
作者的目的是评估淋病奈瑟菌菌株当前的抗菌药物耐药性，以加强匈牙利淋病奈瑟菌的抗菌监测。2011年1月至2014年6月期间，在塞梅维斯大学皮肤病学、性病学和皮肤肿瘤学系的国家性传播感染中心分离出淋病奈瑟菌菌株。
通过最低抑菌浓度测定来确定抗菌药物耐药性。使用淋病奈瑟菌多抗原序列分型作为分子分型方法。
在匈牙利，对目前推荐的广谱头孢菌素耐药情况罕见，但淋病奈瑟菌菌株中出现了阿奇霉素耐药性。
国家治疗指南的修订必须考虑到在匈牙利引起感染的淋病奈瑟菌菌株最常见的序列类型主要对阿奇霉素耐药。
