Nemes-Nikodém Éva, Brunner Alexandra, Pintér Dóra, Mihalik Noémi, Lengyel György, Marschalkó Márta, Kárpáti Sarolta, Szabó Dóra, Ostorházi Eszter
Semmelweis University Department of Dermatology, Venerology and Dermatooncology Budapest Hungary.
Hungarian Defence Forces Research Institute of Military Health Centre Budapest Hungary.
Acta Microbiol Immunol Hung. 2014 Dec;61(4):435-45. doi: 10.1556/AMicr.61.2014.4.5.
Emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae is a major public health concern worldwide. The current study aims to determine the antimicrobial resistance in N. gonorrhoeae and associated molecular typing to enhance gonococcal antimicrobial surveillance in Hungary. In the National N. gonorrhoeae Reference Laboratory of Hungary 187 N. gonorrhoeae infections were detected in 2013, antibiograms were determined for all the isolated strains, and 52 (one index strain from every sexually contact related group) of them were also analysed by the N. gonorrhoeae multi-antigen sequence typing (NG-MAST) method. Twenty-two different NG-MAST sequence types (STs) were identified, of which 8 STs had not been previously described. In Hungary, the highly diversified gonococcal population displayed high resistance to penicillin, ciprofloxacin and tetracycline (the antimicrobials previously recommended for gonorrhoea treatment). Resistance to the currently recommended extended spectrum cephalosporines were rare: only two of the expected strains, an ST 1407 and an ST 210, had cefixime MIC above the resistance breakpoint. By the revision of our National Treatment Guideline, it must be considered, that the azithromycin resistance is about 60% among the four most frequently isolated STs in Hungary.
淋病奈瑟菌中抗菌药物耐药性的出现和传播是全球主要的公共卫生问题。当前的研究旨在确定淋病奈瑟菌的抗菌药物耐药性及相关分子分型，以加强匈牙利淋球菌抗菌药物监测。在匈牙利国家淋病奈瑟菌参考实验室，2013年检测到187例淋病奈瑟菌感染，对所有分离菌株进行了抗菌谱测定，其中52株（每个性接触相关组的一株索引菌株）还采用淋病奈瑟菌多抗原序列分型（NG-MAST）方法进行了分析。鉴定出22种不同的NG-MAST序列类型（STs），其中8种STs此前未曾描述过。在匈牙利，高度多样化的淋球菌群体对青霉素、环丙沙星和四环素（以前推荐用于淋病治疗的抗菌药物）表现出高度耐药性。对目前推荐的广谱头孢菌素的耐药性很少见：预期菌株中只有两株，一株ST 1407和一株ST 210，其头孢克肟最低抑菌浓度高于耐药断点。通过修订我们的国家治疗指南，必须考虑到在匈牙利最常分离出的四种STs中，阿奇霉素耐药率约为60%。
