Krisher Rebecca L, Schoolcraft William B, Katz-Jaffe Mandy G
National Foundation for Fertility Research, Lone Tree, Colorado.
Colorado Center for Reproductive Medicine, Lone Tree, Colorado.
Fertil Steril. 2015 Feb;103(2):333-41. doi: 10.1016/j.fertnstert.2014.12.116.
The advent of advanced omics technologies and the application of these techniques to the analysis of extremely limited material have opened the door to the investigation of embryo physiology in a focused, in-depth approach never before possible. The application of noninvasive metabolomic and proteomic platforms to understanding embryo viability permits the characterization of individual embryos in culture. Initial clinical data have highlighted the promise of these technologies for the development of noninvasive embryo selection criteria. In this way, a complex view of embryo function can be compiled and related to embryo development, quality, and outcome. Application of knowledge gained from omics will transform both our understanding of embryo physiology as well as our ability to select viable embryos for transfer in assisted reproductive technology.
先进组学技术的出现以及这些技术在分析极其有限材料方面的应用，为以前所未有的聚焦、深入方式研究胚胎生理学打开了大门。将非侵入性代谢组学和蛋白质组学平台应用于理解胚胎活力，能够对培养中的单个胚胎进行表征。初步临床数据凸显了这些技术在制定非侵入性胚胎选择标准方面的前景。通过这种方式，可以汇总出胚胎功能的复杂观点，并将其与胚胎发育、质量和结局相关联。从组学中获得的知识应用将改变我们对胚胎生理学的理解以及我们在辅助生殖技术中选择可移植存活胚胎的能力。
