Yu Yan-Yan, Kuang Dan, Yin Xiao-Xv
Chengdu Municipal Center for Disease Control and Prevention, Chengdu, China E-mail :
Asian Pac J Cancer Prev. 2015;16(1):119-24. doi: 10.7314/apjcp.2015.16.1.119.
DICER, one of the microRNA (miRNA) biogenesis proteins, is involved in the maturation of miRNAs and is implicated in cancer development and progression. The results from previous epidemiological studies on associations between DICER rs1057035 polymorphism and cancer risk were inconsistent. Thereforewe performed this meta-analysis to summarize possible associations.
We searched all relevant articles on associations between DICER rs1057035 polymorphism and cancer risk from PubMed, EMBASE, Chinese Biomedical Literature and Chinese National Knowledge Infrastructure until August 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess any associations. Heterogeneity tests, sensitivity analyses and publication bias assessments were also performed in this meta-analysis. All analyses were conducted using STATA software.
Seven case-control studies, including 4,875 cancer cases and 7,800 controls were included in the meta-analysis. Overall, the results indicated that the C allele of DICER rs1057035 polymorphism was significantly associated with decreased cancer risk in allelic comparison, heterozygote and dominant genetic models (C vs T: OR=0.88, 95%CI 0.81-0.95, p=0.002; TC vs TT: OR=0.85, 95%CI 0.77-0.93, p=0.001; CC/TC vs TT: OR=0.86, 95%CI 0.78-0.94, p=0.001). In the subgroup analysis by ethnicity, a significantly decreased cancer risk was found in Asian but not Caucasian populations.
The present meta-analysis suggests that the C allele of the DICER rs1057035 polymorphism probably decreases cancer risk. However, this association may be Asian-specific and the results should be treated with caution. Further well-designed studies based on larger sample sizes and group of populations are needed to validate these findings.
DICER是微小RNA（miRNA）生物合成蛋白之一，参与miRNA的成熟过程，并与癌症的发生和发展有关。先前关于DICER rs1057035多态性与癌症风险之间关联的流行病学研究结果并不一致。因此，我们进行了这项荟萃分析以总结可能的关联。
我们检索了截至2014年8月来自PubMed、EMBASE、中国生物医学文献数据库和中国知网中所有关于DICER rs1057035多态性与癌症风险关联的相关文章。计算比值比（OR）及95%置信区间（CI）以评估任何关联。本荟萃分析还进行了异质性检验、敏感性分析和发表偏倚评估。所有分析均使用STATA软件进行。
荟萃分析纳入了7项病例对照研究，包括4875例癌症病例和7800例对照。总体而言，结果表明在等位基因比较、杂合子和显性遗传模型中，DICER rs1057035多态性的C等位基因与降低的癌症风险显著相关（C与T比较：OR = 0.88，95%CI 0.81 - 0.95，p = 0.002；TC与TT比较：OR = 0.85，95%CI 0.77 - 0.93，p = 0.001；CC/TC与TT比较：OR = 0.86，95%CI 0.78 - 0.94，p = 0.001）。在按种族进行的亚组分析中，发现亚洲人群的癌症风险显著降低，而白种人群未发现此现象。
本荟萃分析表明，DICER rs1057035多态性的C等位基因可能会降低癌症风险。然而，这种关联可能具有亚洲特异性，对结果应谨慎对待。需要进一步基于更大样本量和人群组的精心设计研究来验证这些发现。
