Maryam Zakerinia, Sajad Amirghofran, Maral Namdari, Zahra Lesan, Sima Pooralimohamad, Zeinab Attabac, Zahra Mehravar, Fariba Ebrahimi, Sezaneh Haghpanah, Davood Mehrabani
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran E-mail :
Asian Pac J Cancer Prev. 2015;16(1):239-44. doi: 10.7314/apjcp.2015.16.1.239.
One of the causes of acute leukemia can be exposure to certain chemicals such as pesticides. This study determined the relationship between exposure to pesticides and the occurrence of acute leukemia in Fars province, south of Iran.
Between April 2011 and April 2013 in a case-control study conducted in Nemazee Hospital in Shiraz, Southern Iran; 314 subjects diagnosed with acute leukemia (94 pediatric cases and 220 adults) were enrolled to determine any correlation between exposure to pesticides and the occurrence. Controls (n=314) were matched by sex and age.
There was a history of exposure to pesticides among 85% of pediatric cases and 69% of their controls and 83% of adult cases and 75% of their controls while 87.5% of pediatric cases and 90% of adult cases reported exposure to intermediate and high doses of pesticides and among the controls, the exposure to low doses of pesticides was 70.5% and 65%, respectively. Exposure to indoor pesticides was seen among most of cases and controls. Being a farmer was at a significantly more increased risk of developing acute leukemia in comparison to other jobs, especially for their children.
Exposure to pesticides was shown to be one of the most important causes of acute leukemia. It seems that there is a need to educate the people on public health importance of exposure to pesticides especially during school time to reduce the risk of malignancies during childhood.
急性白血病的病因之一可能是接触某些化学物质，如杀虫剂。本研究确定了伊朗南部法尔斯省接触杀虫剂与急性白血病发生之间的关系。
2011年4月至2013年4月，在伊朗南部设拉子的内马齐医院进行了一项病例对照研究；招募了314名被诊断为急性白血病的受试者（94名儿童病例和220名成人病例），以确定接触杀虫剂与发病之间的任何相关性。对照组（n = 314）按性别和年龄进行匹配。
85%的儿童病例及其75%的对照组、83%的成人病例及其75%的对照组有接触杀虫剂的病史，而87.5%的儿童病例和90%的成人病例报告接触中高剂量的杀虫剂，在对照组中，低剂量杀虫剂的接触率分别为70.5%和65%。大多数病例和对照组都有接触室内杀虫剂的情况。与其他职业相比，农民患急性白血病的风险显著增加，尤其是他们的子女。
接触杀虫剂被证明是急性白血病最重要的病因之一。似乎有必要对人们进行关于接触杀虫剂对公共健康重要性的教育，尤其是在上学期间，以降低儿童期患恶性肿瘤的风险。
