[苯二氮䓬类药物是“天然”药物吗？] - Suppr

Suppr

超能文献

[Do benzodiazepines represent "natural" drugs?].

作者信息

Klotz U

机构信息

Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie, Stuttgart.

出版信息

Klin Wochenschr. 1989 Jan 20;67(2):93-4. doi: 10.1007/BF01735658.

DOI:10.1007/BF01735658

PMID:2564052

Abstract

摘要

相似文献

[Do benzodiazepines represent "natural" drugs?].[苯二氮䓬类药物是“天然”药物吗？]

Klin Wochenschr. 1989 Jan 20;67(2):93-4. doi: 10.1007/BF01735658.

[Racemation of the benzodiazepines camazepam and ketazolam and receptor binding of enantiomers].[苯二氮䓬类药物卡马西泮和氯氮唑仑的消旋作用及对映体的受体结合]

Arzneimittelforschung. 1986 Jun;36(6):893-4.

[Mechanism of action of benzodiazepines].[苯二氮䓬类药物的作用机制]

Cesk Fysiol. 1990;39(6):487-98.

Biochemical properties of the GABA/barbiturate/benzodiazepine receptor-chloride ion channel complex.

Adv Exp Med Biol. 1984;175:205-19. doi: 10.1007/978-1-4684-4805-4_17.

Studies on endogenous ligands (endacoids) for the benzodiazepine/beta carboline binding sites.关于苯二氮䓬/β-咔啉结合位点的内源性配体（内源性类鸦片活性肽）的研究。

Adv Biochem Psychopharmacol. 1986;41:137-48.

Effect of ergot alkaloids on 3H-flunitrazepam binding to mouse brain GABAA receptors.麦角生物碱对3H-氟硝西泮与小鼠脑γ-氨基丁酸A受体结合的影响。

Coll Antropol. 2003;27 Suppl 1:175-82.

Benzodiazepine dependence: clinical and neurobiological aspects.

Adv Biochem Psychopharmacol. 1985;40:185-92.

[Occupation of central benzodiazepine receptors and anxiety].[中枢苯二氮䓬受体的占据与焦虑]

Therapie. 1986 Jan-Feb;41(1):43-7.

The differences in the pharmacological profiles of various benzodiazepine recognition site ligands may be associated with GABAA receptor structural diversity.各种苯二氮䓬识别位点配体的药理学特征差异可能与GABAA受体结构多样性有关。

Adv Biochem Psychopharmacol. 1990;46:73-87.

Molecular models for recognition and activation at the benzodiazepine receptor: a review.苯二氮䓬受体识别与激活的分子模型：综述

Life Sci. 1991;48(7):593-602. doi: 10.1016/0024-3205(91)90533-h.

引用本文的文献

Effects of the benzodiazepine receptor agonist midazolam and antagonist flumazenil on 5-hydroxytryptamine release from guinea-pig intestine in vitro. Indirect support for a "natural" benzodiazepine-like substance in the intestine.

Naunyn Schmiedebergs Arch Pharmacol. 1990 Jan-Feb;341(1-2):1-7. doi: 10.1007/BF00195050.

A first biosynthetic proposal for the in vivo formation of naturally occurring diazepam-like 1,4-benzodiazepines.

J Neural Transm Gen Sect. 1992;88(1):77-82. doi: 10.1007/BF01245038.

本文引用的文献

Synthesis of the skeleton of the morphine molecule by mammalian liver.哺乳动物肝脏对吗啡分子骨架的合成。

Nature. 1987;330(6149):674-7. doi: 10.1038/330674a0.

Morphine and codeine from mammalian brain.来自哺乳动物大脑的吗啡和可待因。

Proc Natl Acad Sci U S A. 1986 Dec;83(24):9784-8. doi: 10.1073/pnas.83.24.9784.

Occurrence of pharmacologically active benzodiazepines in trace amounts in wheat and potato.

Biochem Pharmacol. 1988 Oct 1;37(19):3549-59. doi: 10.1016/0006-2952(88)90384-x.

Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family.γ-氨基丁酸A受体的序列和功能表达显示出一种配体门控受体超家族。

Nature. 1987;328(6127):221-7. doi: 10.1038/328221a0.

Purification of a benzodiazepine from bovine brain and detection of benzodiazepine-like immunoreactivity in human brain.从牛脑中纯化一种苯二氮䓬并检测人脑中苯二氮䓬样免疫反应性。

Proc Natl Acad Sci U S A. 1986 Dec;83(23):9236-40. doi: 10.1073/pnas.83.23.9236.

Diazepam and N-desmethyldiazepam are found in rat brain and adrenal and may be of plant origin.在大鼠大脑和肾上腺中发现了地西泮和N-去甲基地西泮，它们可能源自植物。

J Neural Transm. 1987;70(3-4):383-98. doi: 10.1007/BF01253613.

Endogenous ligands of the benzodiazepine receptor.苯二氮䓬受体的内源性配体。

Pharmacopsychiatry. 1988 Jan;21(1):43-6. doi: 10.1055/s-2007-1014645.

Detection of desmethyldiazepam and diazepam in brain of different species and plants.不同物种和植物大脑中去甲基地西泮和地西泮的检测。

Biochem Pharmacol. 1989 Aug 1;38(15):2473-8. doi: 10.1016/0006-2952(89)90091-9.

Endogenous benzodiazepines in brain: right or wrong?大脑中的内源性苯二氮䓬类物质：是与否？

Trends Neurosci. 1988 Mar;11(3):100. doi: 10.1016/0166-2236(88)90152-x.

Benzodiazepine receptor: demonstration in the central nervous system.苯二氮䓬受体：在中枢神经系统中的显示

Science. 1977 Nov 25;198(4319):849-51. doi: 10.1126/science.918669.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验