Allergy Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain.
Allergy. 2015 May;70(5):576-84. doi: 10.1111/all.12585. Epub 2015 Feb 23.
The EuroPrevall project aimed to develop effective management strategies in food allergy through a suite of interconnected studies and a multidisciplinary integrated approach. To address some of the gaps in food allergy diagnosis, allergen risk management and socio-economic impact and to complement the EuroPrevall population-based surveys, a cross-sectional study in 12 outpatient clinics across Europe was conducted. We describe the study protocol.
Patients referred for immediate food adverse reactions underwent a consistent and standardized allergy work-up that comprised collection of medical history; assessment of sensitization to 24 foods, 14 inhalant allergens and 55 allergenic molecules; and confirmation of clinical reactivity and food thresholds by standardized double-blind placebo-controlled food challenges (DBPCFCs) to milk, egg, fish, shrimp, peanut, hazelnut, celeriac, apple and peach.
A standardized methodology for a comprehensive evaluation of food allergy was developed and implemented in 12 outpatient clinics across Europe. A total of 2121 patients (22.6% <14 years) reporting 8257 reactions to foods were studied, and 516 DBPCFCs were performed.
This is the largest multicentre European case series in food allergy, in which subjects underwent a comprehensive, uniform and standardized evaluation including DBPCFC, by a methodology which is made available for further studies in food allergy. The analysis of this population will provide information on the different phenotypes of food allergy across Europe, will allow to validate novel in vitro diagnostic tests, to establish threshold values for major allergenic foods and to analyse the socio-economic impact of food allergy.
EuroPrevall 项目旨在通过一系列相互关联的研究和多学科综合方法，制定有效的食物过敏管理策略。为了解决食物过敏诊断、过敏原风险管理和社会经济影响方面的一些差距，并补充 EuroPrevall 的基于人群的调查，在欧洲的 12 家门诊诊所进行了一项横断面研究。我们描述了研究方案。
因立即食物不良反应而转介的患者接受了一致和标准化的过敏评估，包括收集病史；评估对 24 种食物、14 种吸入性过敏原和 55 种过敏原分子的致敏情况；通过标准化双盲安慰剂对照食物挑战（DBPCFC）对牛奶、鸡蛋、鱼、虾、花生、榛子、芹菜、苹果和桃进行临床反应和食物阈值的确认。
在欧洲的 12 家门诊诊所中开发并实施了一种用于全面评估食物过敏的标准化方法。共研究了 2121 名（22.6% <14 岁）报告 8257 次食物反应的患者，并进行了 516 次 DBPCFC。
这是欧洲最大的多中心食物过敏病例系列，其中受试者接受了全面、统一和标准化的评估，包括 DBPCFC，采用的方法可用于食物过敏的进一步研究。该人群的分析将提供欧洲不同食物过敏表型的信息，将验证新型体外诊断测试，为主要过敏原食物建立阈值，并分析食物过敏的社会经济影响。
